Evidence map›Paper›PMID 38559248›Full record

ArticlebioRxiv : the preprint server for biology2025

THE HISTONE CHAPERONE SPN1 PRESERVES CHROMATIN PROTECTIONS AT PROMOTERS AND NUCLEOSOME POSITIONING IN OPEN READING FRAMES.

Andrew J Tonsager, Alexis Zukowski, Catherine A Radebaugh, Abigail Weirich, Laurie A Stargell, Srinivas Ramachandran

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrew J TonsagerDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523-1870, USA.ORCID 0009-0005-7696-6877
Alexis ZukowskiDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 80045, USA.ORCID 0000-0002-1212-2254
Catherine A RadebaughDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523-1870, USA.ORCID 0000-0001-8498-9482
Abigail WeirichDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Laurie A StargellDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523-1870, USA.ORCID 0000-0002-9331-3748
Srinivas RamachandranDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 80045, USA.ORCID 0000-0003-2929-1377
Colorado State University · USUniversity of Colorado Denver · US

Funding

Maintenance of cellular memory through replicationR35GM133434 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI RAMACHANDRAN, SRINIVAS · 2019 to 2023
$2.0M
NIGMS NIH HHS R35 GM133434
6 · The paper itself

Abstract

Spn1 is a multifunctional histone chaperone that associates with RNA polymerase II during elongation and is essential for life in eukaryotes. While previous work has elucidated regions of the protein important for its many interactions, it is unknown how these domains contribute to the maintenance of chromatin structure. Here, we employ digestion by micrococcal nuclease followed by single-stranded library preparation and sequencing (MNase-SSP) to characterize chromatin structure in

Identifiers

PMID38559248
PMCPMC10979989
OpenAlexW4392860878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.