Evidence map›Paper›PMID 38559235›Full record

ArticleResearch square2024

Interaction between type 2 diabetes and past COVID-19 on active tuberculosis.

Liz E Calles-Cabanillas, Genesis P Aguillón-Durán, Doris Ayala, José A Caso, Miguel Garza, Mateo Joya-Ayala, America M Cruz-Gonzalez, Raul Loera-Salazar, Ericka Prieto-Martinez, Javier E Rodríguez-Herrera and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Liz E Calles-CabanillasUniversity of Texas Health Science Center at Houston.
Genesis P Aguillón-DuránUniversity of Texas Health Science Center at Houston.
Doris AyalaUniversity of Texas Health Science Center at Houston.
José A CasoUniversity of Texas Health Science Center at Houston.
Miguel GarzaUniversity of Texas Health Science Center at Houston.
Mateo Joya-AyalaUniversity of Texas Rio Grande Valley.
America M Cruz-GonzalezSecretaria de Salud de Tamaulipas.
Raul Loera-SalazarSecretaria de Salud de Tamaulipas.
Ericka Prieto-MartinezSecretaria de Salud de Tamaulipas.
Javier E Rodríguez-HerreraSecretaria de Salud de Tamaulipas.
Esperanza M Garcia-OropesaUniversidad Autónoma de Tamaulipas.
John M ThomasUniversity of Texas Rio Grande Valley.
Miryoung LeeUniversity of Texas Health Science Center at Houston.
Jordi B TorrellesTexas Biomedical Research Institute.
Blanca I RestrepoUniversity of Texas Health Science Center at Houston.
The University of Texas Health Science Center at Houston · USSecretaria de Salud · HNThe University of Texas Rio Grande Valley · USAutonomous University of Tamaulipas · MXTexas Biomedical Research Institute · US

Funding

Social stress as a co-morbidity of age-associated tuberculosisP01AG051428 · NIA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI TURNER, JOANNE · 2016 to 2020
$9.9M
Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)P30AI168439 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI JOANNE TURNER · 2022 to 2026
$6.9M
Bridges to the Baccalaureate Research Training Program at The University of Texas Rio Grande ValleyT34GM137854 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI CHEW, SUE ANNE, GALVEZ, GRISELDA LOPEZ · 2020 to 2024
$1.9M
Role of metabolic Me-macrophages in the pathogenesis of tuberculosis during diabetesR21AI144541 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JAGANNATH, CHINNASWAMY, RESTREPO, BLANCA I · 2020 to 2021
$443k
NIAID NIH HHS P30 AI168439NIAID NIH HHS R21 AI144541NIA NIH HHS P01 AG051428NIGMS NIH HHS T34 GM137854
6 · The paper itself

Abstract

backgroundThe global setback in tuberculosis (TB) prevalence and mortality in the post-COVID-19 era have been partially attributed to pandemic-related disruptions in healthcare systems. The additional biological contribution of COVID-19 to TB is less clear. The goal of this study was to determine if there is an association between COVID-19 in the past 18 months and a new TB episode, and the role played by type 2 diabetes mellitus (DM) comorbidity in this relationship.

methodsA cross-sectional study was conducted among 112 new active TB patients and 373 non-TB controls, identified between June 2020 and November 2021 in communities along the Mexican border with Texas. Past COVID-19 was based on self-report or positive serology. Bivariable/multivariable analysis were used to evaluate the odds of new TB in hosts with past COVID-19 and/or DM status.

resultsThe odds of new TB were higher among past COVID-19 cases vs. controls, but only significant among DM patients (aOR 2.3). The odds of TB given DM was 2.7-fold among participants without past COVID-19 and increased to 7.9-fold among those with past COVID-19.

conclusionDM interacts with past COVID-19 synergistically to magnify the risk of TB. Latent TB screening and prophylactic treatment, if positive, is recommended in this COVID-19/DM/latent TB high-risk group.

Indexed as

COVID-19cross-sectional studyMexicotuberculosisType 2 diabetes

Identifiers

PMID38559235
PMCPMC10980154
OpenAlexW4392819193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.