Evidence map›Paper›PMID 38559224›Full record

ArticlebioRxiv : the preprint server for biology2024

Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy.

Yu Feng, Keziah S Diego, Zhe Dong, Zoé Christenson Wick, Lucia Page-Harley, Veronica Page-Harley, Julia Schnipper, Sophia I Lamsifer, Zachary T Pennington, Lauren M Vetere and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Yu FengIcahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0001-9068-3746
Keziah S DiegoIcahn School of Medicine at Mount Sinai, New York, NY.
Zhe DongIcahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-7366-8939
Zoé Christenson WickIcahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-2752-0140
Lucia Page-HarleyIcahn School of Medicine at Mount Sinai, New York, NY.
Veronica Page-HarleyIcahn School of Medicine at Mount Sinai, New York, NY.
Julia SchnipperIcahn School of Medicine at Mount Sinai, New York, NY.
Sophia I LamsiferIcahn School of Medicine at Mount Sinai, New York, NY.
Zachary T PenningtonIcahn School of Medicine at Mount Sinai, New York, NY.
Lauren M VetereIcahn School of Medicine at Mount Sinai, New York, NY.
Paul A PhilipsbergIcahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0001-9332-0342
Ivan SolerIcahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-3639-9282
Albert JurkowskiIcahn School of Medicine at Mount Sinai, New York, NY.
Christin J RosadoIcahn School of Medicine at Mount Sinai, New York, NY.
Nadia N KhanIcahn School of Medicine at Mount Sinai, New York, NY.ORCID 0009-0002-9671-8238
Denise J CaiIcahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0002-7729-0523
Tristan ShumanIcahn School of Medicine at Mount Sinai, New York, NY.ORCID 0000-0003-2310-6142

Funding

Circuit Mechanisms of Retrospective Memory-LinkingR01MH120162 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Denise Jade Cai · 2020 to 2026
$3.9M
Research Training in the Neuroscience of AgingT32AG049688 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph Michael Castellano, PATRICK R HOF · 2015 to 2026
$3.0M
Circuits Driving Spatial Coding Deficits in EpilepsyR01NS116357 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHUMAN, TRISTAN · 2021 to 2025
$2.8M
How does the brain maximize storage capacity?DP2MH122399 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DENISE JADE · 2019 to 2020
$2.6M
Entorhinal-hippocampal interactions during progressive memory impairments in mouse models of Alzheimer's disease pathologyRF1AG072497 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SHUMAN, TRISTAN · 2022 to 2024
$2.4M
Closed-loop Control of Interneuron Spike Timing in EpilepsyR01NS136590 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Tristan Shuman · 2024 to 2026
$1.8M
Fear and anxiety circuit mechanisms in anterior hypothalamic nucleusR56MH132959 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DENISE JADE · 2023 to 2024
$1.3M
Closed-Loop Control of Dentate Inhibitory Timing in Healthy and Epileptic MiceF32NS116416 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHRISTENSON WICK, ZOÉ · 2020 to 2023
$206k
Interneuron and Network Dysfunction in a Mouse Model of Alzheimer's DiseaseF31AG069496 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI VETERE, LAUREN · 2020 to 2022
$134k
Progression of Entorhinal-hippocampal Spatial and Emotional Processing Deficits in a Mouse Model of Temporal Lobe EpilepsyF99NS135813 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SOLER, IVAN · 2023 to 2024
$94k
NIA NIH HHS F31 AG069496NIA NIH HHS RF1 AG072497NIA NIH HHS T32 AG049688NIMH NIH HHS DP2 MH122399NIMH NIH HHS R01 MH120162NIMH NIH HHS R56 MH132959NINDS NIH HHS F32 NS116416NINDS NIH HHS F99 NS135813NINDS NIH HHS R01 NS116357NINDS NIH HHS R01 NS136590
6 · The paper itself

Abstract

Temporal lobe epilepsy (TLE) causes pervasive and progressive memory impairments, yet the specific circuit changes that drive these deficits remain unclear. To investigate how hippocampal-entorhinal dysfunction contributes to progressive memory deficits in epilepsy, we performed simultaneous

Identifiers

PMID38559224
PMCPMC10979962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.