Evidence map›Paper›PMID 38559215›Full record

ArticlebioRxiv : the preprint server for biology2024

Stalling of Transcription by Putative G-quadruplex Sequences and CRISPR-dCas9.

Mohammed Enamul Hoque, Mohammad Lutful Kabir, Sajad Shiekh, Hamza Balci, Soumitra Basu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mohammed Enamul HoqueDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, USA.
Mohammad Lutful KabirDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, USA.
Sajad ShiekhDepartment of Physics, Kent State University, Kent, OH 44242, USA.
Hamza BalciDepartment of Physics, Kent State University, Kent, OH 44242, USA.ORCID 0000-0002-0273-4871
Soumitra BasuDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44242, USA.
Kent State University · US

Funding

Targeting Promoter G-quadruplexes with CRISPR-dCas9 for Transcription RegulationR15GM146180 · NIGMS · KENT STATE UNIVERSITY · PI BALCI, HAMZA · 2022 to 2023
$539k
NIGMS NIH HHS R15 GM146180
6 · The paper itself

Abstract

Putative G-quadruplex forming sequences (PQS) have been identified in promoter sequences of prominent genes that are implicated among others in cancer and neurological disorders. We explored mechanistic aspects of CRISPR-dCas9-mediated gene expression regulation, which is transient and sequence specific unlike alternative approaches that lack such specificity or create permanent mutations, using the PQS in tyrosine hydroxylase (

Indexed as

CRISPRdCas9G-quadruplexRNA PolymeraseTranscription Regulation

Identifiers

PMID38559215
PMCPMC10979993
OpenAlexW4392891670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.