Evidence map›Paper›PMID 38559208›Full record

ArticlebioRxiv : the preprint server for biology2024

Molecular Mechanisms of Genotype-Dependent Lifespan Variation Mediated by Caloric Restriction: Insight from Wild Yeast Isolates.

Samantha McLean, Mitchell Lee, Weiqiang Liu, Rohil Hameed, Vikas Anil Gujjala, Xuming Zhou, Matt Kaeberlein, Alaattin Kaya

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Samantha McLeanDepartment of Biology, Virginia Commonwealth University, Richmond, VA 23284 USA.
Mitchell LeeDepartment of Pathology, University of Washington, Seattle, WA, 98195, USA.
Weiqiang LiuKey Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, Institute of Zoology, Beijing, China.ORCID 0000-0002-2429-8791
Rohil HameedDepartment of Biology, Virginia Commonwealth University, Richmond, VA 23284 USA.
Vikas Anil GujjalaDepartment of Biology, Virginia Commonwealth University, Richmond, VA 23284 USA.
Xuming ZhouKey Laboratory of Animal Ecology and Conservation Biology, Chinese Academy of Sciences, Institute of Zoology, Beijing, China.ORCID 0000-0002-1100-6294
Matt KaeberleinDepartment of Pathology, University of Washington, Seattle, WA, 98195, USA.ORCID 0000-0002-1311-3421
Alaattin KayaDepartment of Biology, Virginia Commonwealth University, Richmond, VA 23284 USA.ORCID 0000-0002-6132-5197
Virginia Commonwealth University · USChinese Academy of Sciences · CNCenter for Infectious Disease Research · USUniversity of Washington · US

Funding

University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Maitreya J Dunham · 1995 to 2026
$27.1M
The role of mito-nuclear communication in the adaptation to mitochondrial dysfunction and stress resistanceR35GM150858 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Alaattin Kaya · 2023 to 2026
$1.8M
MOLECULAR MECHANISMS OF NATURAL LIFESPAN VARIATIONK01AG060040 · NIA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KAYA, ALAATTIN · 2019 to 2022
$515k
NIA NIH HHS K01 AG060040NIA NIH HHS P30 AG013280NIGMS NIH HHS R35 GM150858
6 · The paper itself

Abstract

Caloric restriction (CR) is known to extend lifespan across different species and holds great promise for preventing human age-onset pathologies. However, two major challenges exist. First, despite extensive research, the mechanisms of lifespan extension in response to CR remain elusive. Second, genetic differences causing variations in response to CR and genetic factors contributing to variability of CR response on lifespan are largely unknown. Here, we took advantage of natural genetic variation across 46 diploid wild yeast isolates of

Indexed as

Caloric restrictiongenotype variationlifespanmetabolismyeast

Identifiers

PMID38559208
PMCPMC10979966
OpenAlexW4392924852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.