Evidence map›Paper›PMID 38559164›Full record

ArticlebioRxiv : the preprint server for biology2024

Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer's Disease fly models.

Ye-Jin Park, Tzu-Chiao Lu, Tyler Jackson, Lindsey D Goodman, Lindsey Ran, Jiaye Chen, Chung-Yi Liang, Erin Harrison, Christina Ko, Ao-Lin Hsu and 4 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Ye-Jin ParkHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8066-4194
Tzu-Chiao LuHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9942-2307
Tyler JacksonHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2988-4340
Lindsey D GoodmanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-9255-3811
Lindsey RanHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0004-3213-9573
Jiaye ChenHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9654-1968
Chung-Yi LiangHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-3352-775X
Erin HarrisonHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0001-7836-7385
Christina KoHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Ao-Lin HsuInstitute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0002-2864-3134
Shinya YamamotoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2172-8036
Yanyan QiHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
Hugo J BellenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-5992-5989
Hongjie LiHuffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-7332-7122
Baylor College of Medicine · USNational Yang Ming Chiao Tung University · TW

Funding

Transposon induced disruption of most Drosophila genesR01GM067858 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2003 to 2020
$15.7M
Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila ModelsU01AG072439 · NIA · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J, BOTAS, JUAN · 2021 to 2025
$8.4M
A Comprehensive Resource for Manipulating the Drosophila GenomeR24OD031447 · OD · BAYLOR COLLEGE OF MEDICINE · PI HUGO J BELLEN, Oguz Kanca · 2021 to 2026
$5.2M
Mutidisciplinary Training;Brain Disorders &DevelopmentT32NS043124 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SWANN, JOHN WILLIAM · 2002 to 2021
$4.6M
The Clinical Translational Research Certificate of Added Qualification ProgramT32GM136554 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Melissa Suter, IGNATIA B VAN DEN VEYVER · 2020 to 2026
$3.0M
IMPACTS OF GLIAL LIPID DROPLETS ON OXIDATIVE STRESS AND NEURODEGENERATION IN ALZHEIMER'S DISEASER01AG073260 · NIA · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2021 to 2025
$2.6M
UNDERSTANDING THE ROLE OF TM2D FAMILY GENES IN NOTCH SIGNALING AND ALZHEIMER'S DISEASERF1AG071557 · NIA · BAYLOR COLLEGE OF MEDICINE · PI YAMAMOTO, SHINYA · 2021 to 2021
$1.2M
NIA NIH HHS R01 AG073260NIA NIH HHS RF1 AG071557NIA NIH HHS U01 AG072439NIGMS NIH HHS R01 GM067858NIGMS NIH HHS T32 GM136554NIH HHS R24 OD031447NINDS NIH HHS T32 NS043124
6 · The paper itself

Abstract

Peripheral tissues become disrupted in Alzheimer's Disease (AD). However, a comprehensive understanding of how the expression of AD-associated toxic proteins, Aβ42 and Tau, in neurons impacts the periphery is lacking. Using

Indexed as

agingAlzheimer’s Diseasecell atlasDrosophilaneurodegenerationsingle-nucleus RNA-seq

Identifiers

PMID38559164
PMCPMC10979927
OpenAlexW4392748018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.