Evidence map›Paper›PMID 38559136›Full record

ArticlebioRxiv : the preprint server for biology2024

Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition.

Jocelyn M Richard, Anne Armstrong, Bailey Newell, Preethi Muruganandan, Patricia H Janak, Benjamin T Saunders

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jocelyn M RichardDepartment of Neuroscience, University of Minnesota, Minneapolis, MN.ORCID 0000-0001-5750-0418
Anne ArmstrongDepartment of Psychological and Brain Sciences, Krieger School of Arts and Sciences Johns Hopkins University, Baltimore, MD.
Bailey NewellDepartment of Neuroscience, University of Minnesota, Minneapolis, MN.ORCID 0009-0002-4023-5181
Preethi MuruganandanDepartment of Neuroscience, University of Minnesota, Minneapolis, MN.
Patricia H JanakDepartment of Psychological and Brain Sciences, Krieger School of Arts and Sciences Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-3333-9049
Benjamin T SaundersDepartment of Neuroscience, University of Minnesota, Minneapolis, MN.ORCID 0000-0002-4733-1101
University of Minnesota · USJohns Hopkins University · US

Funding

Glutamatergic basal forebrain neurons in aversion-resistant drinkingR01AA028770 · NIAAA · UNIVERSITY OF MINNESOTA · PI RICHARD, JOCELYN M · 2021 to 2025
$2.2M
Amygdala neural circuits in alcohol intakeR01AA027213 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI JANAK, PATRICIA H. · 2019 to 2023
$2.1M
Ventral pallidal circuitry in alcohol seeking and reinstatement by stressR00AA025384 · NIAAA · UNIVERSITY OF MINNESOTA · PI RICHARD, JOCELYN M · 2018 to 2020
$747k
Ventral pallidal circuitry in alcohol seeking and reinstatement by stressK99AA025384 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI RICHARD, JOCELYN M · 2017 to 2017
$139k
NIAAA NIH HHS K99 AA025384NIAAA NIH HHS R00 AA025384NIAAA NIH HHS R01 AA027213
6 · The paper itself

Abstract

Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously been established. Here, we tested the impact of optogenetic inhibition of ventral pallidum on Pavlovian-conditioned alcohol-seeking in male Long Evans rats. Rats underwent Pavlovian conditioning with an auditory cue predicting alcohol delivery to a reward port and a control cue predicting no alcohol delivery, until they consistently entered the reward port more during the alcohol cue than the control cue. We then tested the within-session effects of optogenetic inhibition during 50% of cue presentations. We found that optogenetic inhibition of ventral pallidum during the alcohol cue reduced port entry likelihood and time spent in the port, and increased port entry latency. Overall, these results suggest that normal ventral pallidum activity is necessary for Pavlovian alcohol-seeking.

Identifiers

PMID38559136
PMCPMC10980019
OpenAlexW4392860841

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.