Evidence map›Paper›PMID 38559132›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Bicuspid Aortic Valve Disease With Early Onset Complications: Characteristics And Aortic Outcomes.

Maximilian A Selbst, Megan K Laughlin, Colin R Ward, Hector Michelena, Anna Sabate-Rotes, Lisa Bianco, Julie De Backer, Laura Muiño Mosquera, Anji T Yetman, Malenka M Bissell and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Maximilian A SelbstDepartment of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0009-0006-4544-1936
Megan K LaughlinDepartment of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Colin R WardDepartment of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Hector MichelenaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Anna Sabate-RotesDepartment of Pediatric Cardiology, Hospital Vall d'Hebron, Facultad de Medicina, Universidad Autònoma Barcelona, Barcelona, Spain.
Lisa BiancoDepartment of Pediatric Cardiology, Hospital Vall d'Hebron, Facultad de Medicina, Universidad Autònoma Barcelona, Barcelona, Spain.
Julie De BackerCentre for Medical Genetics, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0001-8878-1507
Laura Muiño MosqueraCentre for Medical Genetics, Ghent University Hospital, Ghent, Belgium.
Anji T YetmanChildren's Hospital and Medical Center, University of Nebraska, Omaha, Nebraska.
Malenka M BissellDepartment of Biomedical Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Maria Grazia AndreassiConsiglio Nazionale delle Richerche (CNR), Instituto di Fisiologia Clinica, Pisa, Italy.
Ilenia FoffaConsiglio Nazionale delle Richerche (CNR), Instituto di Fisiologia Clinica, Pisa, Italy.
Dawn S HuiDepartment of Cardiothoracic Surgery, University of Texas Health Science Center San Antonio, Texas.
Anthony CaffarelliDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California.
Yuli Y KimDivision of Cardiovascular Medicine, The Hospital of the University of Pennsylvania, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Dongchuan GuoDepartment of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Rodolfo CitroCardio-Thoracic and Vascular Department, University Hospital "San Giovanni di Dio e Ruggi d'Aragona," Salerno, Italy.
Margot De MarcoDepartment of Medicine, Surgery and Dentistry Schola Medica Salernitana, University of Salerno, Baronissi, Italy.
Justin T TretterHeart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Shaine A MorrisCumming School of Medicine, University of Calgary, Calgary, Canada.
Kim L McBrideDepartment of Anesthesiology, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts.
Simon C BodyDepartment of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
EBAV Investigators
Siddharth K PrakashDepartment of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas.

Funding

Genetic Etiology of Bicuspid Aortic Valve DiseaseR01HL114823 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BODY, SIMON C · 2012 to 2016
$2.1M
Genetic Basis of Early Onset Bicuspid Aortic Valve DiseaseR01HL137028 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI PRAKASH, SIDDHARTH KUMAR · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL114823NHLBI NIH HHS R01 HL137028
6 · The paper itself

Abstract

Bicuspid aortic valve (BAV) is the most common congenital heart malformation in adults but can also cause childhood-onset complications. In multicenter study, we found that adults who experience significant complications of BAV disease before age 30 are distinguished from the majority of BAV cases that manifest after age 50 by a relatively severe clinical course, with higher rates of surgical interventions, more frequent second interventions, and a greater burden of congenital heart malformations. These observations highlight the need for prompt recognition, regular lifelong surveillance, and targeted interventions to address the significant health burdens of patients with early onset BAV complications.

Indexed as

Aortic surgeryBicuspid Aortic ValveCoarctationOutcomesThoracic Aortic Aneurysms

Identifiers

PMID38559132
PMCPMC10980111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.