Evidence map›Paper›PMID 38559121›Full record

ArticlebioRxiv : the preprint server for biology2024

End resection and telomere healing of DNA double-strand breaks during nematode programmed DNA elimination.

Brandon Estrem, Richard E Davis, Jianbin Wang

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Brandon EstremDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, 37996, USA.
Richard E DavisDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Jianbin WangDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, 37996, USA.ORCID 0000-0003-3155-894X
University of Tennessee at Knoxville · USUniversity of Colorado Denver · US

Funding

Programmed DNA Elimination in Parasitic NematodesR01AI155588 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Jianbin Wang · 2020 to 2026
$3.0M
Chromatin diminution in nematodesR01AI114054 · NIAID · UNIVERSITY OF COLORADO DENVER · PI DAVIS, RICHARD E. · 2015 to 2019
$2.5M
A genetic model for metazoan programmed DNA eliminationR01GM151551 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Jianbin Wang · 2023 to 2026
$1.2M
NIAID NIH HHS R01 AI114054NIAID NIH HHS R01 AI155588NIGMS NIH HHS R01 GM151551
6 · The paper itself

Abstract

Most DNA double-strand breaks (DSBs) are harmful to genome integrity. However, some forms of DSBs are essential to biological processes, such as meiotic recombination and V(D)J recombination. DSBs are also required for programmed DNA elimination (PDE) in ciliates and nematodes. In nematodes, the DSBs are healed with telomere addition. While telomere addition sites have been well-characterized, little is known regarding the DSBs that fragment nematode chromosomes. Here, we used embryos from the nematode

Indexed as

AscarisDNA double-strand breakend resectionEND-seqmicronucleinematodeParascarisprogrammed DNA eliminationtelomere addition

Identifiers

PMID38559121
PMCPMC10980081
OpenAlexW4392894291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.