Evidence map›Paper›PMID 38559075›Full record

ArticlebioRxiv : the preprint server for biology2024

RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples.

Steven Henikoff, Ye Zheng, Ronald M Paranal, Yiling Xu, Jacob E Greene, Jorja G Henikoff, Zachary R Russell, Frank Szulzewsky, H Nayanga Thirimanne, Sita Kugel and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Steven HenikoffBasic Science Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-7621-8685
Ye ZhengBasic Science Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-8806-2761
Ronald M ParanalHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-4263-4621
Yiling XuBasic Science Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jacob E GreeneBasic Science Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-3016-7296
Jorja G HenikoffBasic Science Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-7670-5101
Zachary R RussellHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0003-9659-6389
Frank SzulzewskyHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-5710-9590
H Nayanga ThirimanneHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sita KugelHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-7202-187X
Eric C HollandHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-3792-7120
Kami AhmadBasic Science Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-8572-6182
Fred Hutch Cancer Center · USUniversity of Washington · USHoward Hughes Medical Institute · USHuntsman Cancer Institute · US

Funding

TRAINING IN CANCER BIOLOGY &TRANSPLANTATIONT32CA009515 · NCI · UNIVERSITY OF WASHINGTON · PI NANCY ELLEN DAVIDSON, Effie W Petersdorf · 1985 to 2026
$16.2M
The role and mechanism of alternative RNA splice variants and gene fusions as drivers of cancerR35CA253119 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric C. Holland · 2021 to 2026
$6.5M
Bridging the gap: joint modeling of single-cell 1D and 3D genomicsR00HG012797 · NHGRI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI YE ZHENG · 2024 to 2026
$747k
Bridging the gap: joint modeling of single-cell 1D and 3D genomicsK99HG012797 · NHGRI · FRED HUTCHINSON CANCER CENTER · PI ZHENG, YE · 2023 to 2024
$132k
NCI NIH HHS R35 CA253119NCI NIH HHS T32 CA009515NHGRI NIH HHS K99 HG012797NHGRI NIH HHS R00 HG012797
6 · The paper itself

Abstract

Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our FFPE-CUTAC method for mapping RNA Polymerase II (RNAPII) genome-wide in formalin-fixed paraffin-embedded (FFPE) sections. We demonstrate global RNAPII elevations in mouse gliomas and assorted human tumors in small clinical samples and discover regional elevations corresponding to

Indexed as

CentromeresEpigenomicsGene RegulationHER2 amplificationMeningiomaMitochondrial DNAWhole-arm aneuploidy

Identifiers

PMID38559075
PMCPMC10979862
OpenAlexW4392528886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.