ArticlebioRxiv : the preprint server for biology2024
Bioluminescence Imaging of Potassium Ion Using a Sensory Luciferin and an Engineered Luciferase.
Shengyu Zhao, Ying Xiong, Ranganayakulu Sunnapu, Yiyu Zhang, Xiaodong Tian, Hui-Wang Ai
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors at 2 institutions in 1 country.
Shengyu ZhaoDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Ying XiongDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Ranganayakulu SunnapuDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Yiyu ZhangDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Xiaodong TianDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Hui-Wang AiDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.ORCID 0000-0002-5664-3270 University of Virginia · USFrederick National Laboratory for Cancer Research · US
Funding
Next-Gen Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound ProcessingR01EB033172 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai, Thanos Tzounopoulos · 2022 to 2026
$3.3MAn Integrated Fluorescent Biosensor, Imaging, and Analysis Toolkit for Islet BiologicsR01DK122253 · NIDDK · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2020 to 2023
$1.6MFluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's DiseaseRF1AG077773 · NIA · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2022 to 2022
$1.6MNext-Generation ATP-Independent Luciferases, Luciferins, and Bioluminescent Calcium IndicatorsR01EB035430 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai · 2024 to 2026
$1.4MNIA NIH HHS RF1 AG077773NIBIB NIH HHS R01 EB033172NIBIB NIH HHS R01 EB035430NIDDK NIH HHS R01 DK122253
6 · The paper itselfAbstract
Bioluminescent indicators are power tools for studying dynamic biological processes. In this study, we present the generation of novel bioluminescent indicators by modifying the luciferin molecule with an analyte-binding moiety. Specifically, we have successfully developed the first bioluminescent indicator for potassium ions (K
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PMID38559024
PMCPMC10980066
OpenAlexW4392860412
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