Evidence map›Paper›PMID 38559014›Full record

ArticleResearch square2024

Distinct multimodal biological and functional profiles of symptom-based subgroups in recent-onset psychosis.

Nikolaos Koutsouleris, Madalina-Octavia Buciuman, Clara Sophie Vetter, Clara Francesca Charlotte Weyer, Paul Zhutovsky, Santiago Tovar Perdomo, Adyasha Khuntia, Yuri Milaneschi, David Popovic, Anne Ruef and 18 more

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In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Nikolaos KoutsoulerisLudwig-Maximilians-University.ORCID 0000-0001-6825-6262
Madalina-Octavia BuciumanLudwig-Maximilians-University.
Clara Sophie VetterLudwig-Maximilians-University.
Clara Francesca Charlotte WeyerLudwig-Maximilians-University.
Paul ZhutovskyAmstedam Medical Center.
Santiago Tovar PerdomoLudwig-Maximilians-University.
Adyasha KhuntiaAmsterdam UMC, Vrije Universiteit/GGZ inGeest.
Yuri MilaneschiAmsterdam UMC, Vrije Universiteit/GGZ inGeest.ORCID 0000-0002-3697-6617
David PopovicLudwig-Maximilians-University.ORCID 0000-0002-2367-9437
Anne RuefLMU.
Dominic DwyerAston University.
Katharine ChisholmAston University.ORCID 0000-0002-0575-0789
Lana KambeitzUniversity of Cologne, Faculty of Medicine and University Hospital.
Linda AntonucciFaculty of Medicine and University Hospital, University of Cologne, Cologne.
Stephan RuhrmannFaculty of Medicine and University Hospital, University of Cologne, Cologne.ORCID 0000-0002-6022-2364
Joseph KambeitzFaculty of Medicine and University Hospital, University of Cologne, Cologne.ORCID 0000-0002-8988-3959
Anita Riecher-RösslerUniversity of Basel.ORCID 0000-0001-6361-8789
Rachel UpthegroveUniversity of Birmingham.ORCID 0000-0001-8204-5103
Raimo SalokangasUniversity of Turku.
Jarmo HietalaUniversity of Turku.ORCID 0000-0002-3179-6780
Christos PantelisUniversity of Melbourne.ORCID 0000-0002-9565-0238
Rebekka LencerUniversity of Melbourne.
Eva MeisenzahlUniversity of Melbourne.
Stephen WoodUniversity of Melbourne.
Paolo BrambillaUniversity of Milan.ORCID 0000-0002-4021-8456
Stefan BorgwardtUniversity of Lübeck.ORCID 0000-0002-5792-3987
Alessandro BertolinoGroup of Psychiatric Neuroscience, Department of Basic Medical Science, Neuroscience and Sense Organs, Aldo Moro University, Bari.
Peter FalkaiUniversity Hospital LMU.

Funding

ProNET: Psychosis-Risk Outcomes NetworkU01MH124639 · NIMH · YALE UNIVERSITY · PI CARRIE E BEARDEN, JOHN M KANE · 2020 to 2026
$81.2M
NIMH NIH HHS U01 MH124639Wellcome Trust
6 · The paper itself

Abstract

Symptom heterogeneity characterizes psychotic disorders and hinders the delineation of underlying biomarkers. Here, we identify symptom-based subtypes of recent-onset psychosis (ROP) patients from the multi-center PRONIA (Personalized Prognostic Tools for Early Psychosis Management) database and explore their multimodal biological and functional signatures. We clustered N = 328 ROP patients based on their maximum factor scores in an exploratory factor analysis on the

Indexed as

early psychosisfactor analysisfunctioning trajectoriesgray matter volumeneurocognitionpolygenic risk score

Identifiers

PMID38559014
PMCPMC10980097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.