Evidence map›Paper›PMID 38558994›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Increasing intra- and inter-subtype HIV diversity despite declining HIV incidence in Uganda.

Seungwon Kim, Godfrey Kigozi, Michael A Martin, Ronald M Galiwango, Thomas C Quinn, Andrew D Redd, Robert Ssekubugu, David Bonsall, Deogratius Ssemwanga, Andrew Rambaut and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Seungwon KimDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5509-0969
Godfrey KigoziRakai Health Sciences Program, Kalisizo, Uganda.
Michael A MartinDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ronald M GaliwangoRakai Health Sciences Program, Kalisizo, Uganda.
Thomas C QuinnRakai Health Sciences Program, Kalisizo, Uganda.
Andrew D ReddDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Robert SsekubuguRakai Health Sciences Program, Kalisizo, Uganda.
David BonsallBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Deogratius SsemwangaMedical Research Council (MRC)/Uganda Virus Research Institute (UVRI) and London School of Hygiene and Tropical Medicine (LSHTM) Uganda Research Unit, Entebbe, Uganda.
Andrew RambautInstitute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
Joshua T HerbeckDepartment of Global Health, University of Washington, Seattle, WA, USA.
Steven J ReynoldsRakai Health Sciences Program, Kalisizo, Uganda.
Brian FoleyTheoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Lucie Abeler-DörnerBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Christophe FraserBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Oliver RatmannDepartment of Mathematics, Imperial College London, London, England, United Kingdom.
Joseph KagaayiRakai Health Sciences Program, Kalisizo, Uganda.
Oliver LaeyendeckerDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
M Kate GrabowskiDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Funding

LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
Epidemiology and Impact of the HIV, NCD, and Urbanization Syndemic in AfricaR01HL152813 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2021 to 2025
$7.8M
RCT to reduce HIV acquisition and viral load among migrants, Rakai, UgandaR01MH115799 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM, WAWER, MARIA J · 2018 to 2022
$2.9M
Long-term impact of universal treatment and dolutegravir on population HIV virologic and incidence outcomes in Africa: The LONGVIEW StudyR01AI155080 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRABOWSKI, MARY KATHRYN · 2021 to 2024
$2.5M
Hard-to-Reach Populations: Implications for Ending the AIDS EpidemicR01AI143333 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2019 to 2022
$2.4M
HIV Incidence, Transmission Dynamics and Combination HIV Prevention: Rakai UgandaR01AI110324 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H · 2014 to 2016
$2.4M
Medical Research Council MC_UU_00033/1NHLBI NIH HHS R01 HL152813NIAID NIH HHS R01 AI110324NIAID NIH HHS R01 AI143333NIAID NIH HHS R01 AI155080NIAID NIH HHS UM1 AI068613NIMH NIH HHS R01 MH115799
6 · The paper itself

Abstract

HIV incidence has been declining in Africa with scale-up of HIV interventions. However, there is limited data on HIV evolutionary trends in African populations with waning epidemics. We evaluated changes in HIV viral diversity and genetic divergence in southern Uganda over a twenty-five-year period spanning the introduction and scale-up of HIV prevention and treatment programs using HIV sequence and survey data from the Rakai Community Cohort Study, an open longitudinal population-based HIV surveillance cohort.

Identifiers

PMID38558994
PMCPMC10980117

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.