Evidence map›Paper›PMID 38558990›Full record

ArticleResearch square2024

Induction of complementary immunogenic necroptosis and apoptosis cell death pathways inhibits cancer metastasis and relapse.

Christopher Egbulefu, Kvar Black, Xinming Su, Partha Karmakar, LeMoyne Habimana-Griffin, Gail Sudlow, Julie Prior, Ezeugo Chukwu, Alex Zheleznyak, Baogang Xu and 11 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Christopher EgbulefuDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.ORCID 0000-0002-1455-5125
Kvar BlackDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Xinming SuDepartment of Medicine, Washington University in St. Louis, MO 63110, USA.
Partha KarmakarDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
LeMoyne Habimana-GriffinDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Gail SudlowDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Julie PriorDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Ezeugo ChukwuDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Alex ZheleznyakDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Baogang XuDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Yalin XuDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Alison EsserDepartment of Medicine, Washington University in St. Louis, MO 63110, USA.
Matthew MixdorfDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Evan MossDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.ORCID 0009-0001-0528-5880
Brad ManionDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Nathan ReedDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.
Matthew GubinDepartment of Pathology and Immunology, Washington University in St. Louis, MO 63110, USA.ORCID 0000-0001-7443-2752
Chieh-Yu LinDepartment of Pathology and Immunology, Washington University in St. Louis, MO 63110, USA.
Robert SchreiberDepartment of Pathology and Immunology, Washington University in St. Louis, MO 63110, USA.
Katherine WeilbaecherDepartment of Medicine, Washington University in St. Louis, MO 63110, USA.
Samuel AchilefuDepartment of Radiology, Washington University in St. Louis, MO 63110, USA.ORCID 0000-0002-3133-6717
Trinity Washington University · USBipar · FRWashington University in St. Louis · USSouthwestern Medical Center

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPYR01CA260855 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2021 to 2025
$3.5M
TARGETING AML-STROMAL INTERACTIONSR01CA152329 · NCI · WASHINGTON UNIVERSITY · PI DIPERSIO, JOHN F. · 2011 to 2015
$2.5M
Imaging Goggles for Fluorescence-Guided SurgeryR01EB030987 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL, BURAS, WILLIAM ROBINSON · 2021 to 2024
$2.1M
MOLECULAR PROBES AND METHODS FOR FLUORESCENCE LIFETIME TOMOGRAPHY AND MICROSCOPYR01EB008111 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2009 to 2012
$1.9M
RETARGETING AGENTS TO TREAT AMLR01CA194552 · NCI · WASHINGTON UNIVERSITY · PI DIPERSIO, JOHN F. · 2015 to 2017
$1.1M
IVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599k
Multispectral Optoacoustic Tomography (MSOT) SystemS10OD025264 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2018 to 2018
$544k
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA152329NCI NIH HHS R01 CA194552NCI NIH HHS R01 CA260855NIBIB NIH HHS R01 EB008111NIBIB NIH HHS R01 EB030987NIH HHS S10 OD025264NIH HHS S10 OD027042
6 · The paper itself

Abstract

Interactions of light-sensitive drugs and materials with Cerenkov radiation-emitting radiopharmaceuticals generate cytotoxic reactive oxygen species (ROS) to inhibit localized and disseminated cancer progression, but the cell death mechanisms underlying this radionuclide stimulated dynamic therapy (RaST) remain elusive. Using ROS-regenerative nanophotosensitizers coated with a tumor-targeting transferrin-titanocene complex (TiO

Identifiers

PMID38558990
PMCPMC10980095
OpenAlexW4392714250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.