Evidence map›Paper›PMID 38558974›Full record

ArticlebioRxiv : the preprint server for biology2024

Rem2 interacts with CaMKII at synapses and restricts long-term potentiation in hippocampus.

Rabia Anjum, Vernon R J Clarke, Yutaro Nagasawa, Hideji Murakoshi, Suzanne Paradis

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Rabia AnjumDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, United States of America.
Vernon R J ClarkeDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Yutaro NagasawaDepartment of Physiological Sciences, The Graduate University for Advanced Studies; Hayama, Kanagawa 240-0193, Japan.ORCID 0000-0002-7471-268X
Hideji MurakoshiDepartment of Physiological Sciences, The Graduate University for Advanced Studies; Hayama, Kanagawa 240-0193, Japan.
Suzanne ParadisDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, United States of America.ORCID 0000-0002-5190-4240
Brandeis University · USThe Graduate University for Advanced Studies, SOKENDAI · JPNorthwestern University · US

Funding

Semaphorin-Dependent GABAergic Synapse Formation: A Novel Approach to Increasing Inhibition in the Intact BrainR01NS065856 · NINDS · BRANDEIS UNIVERSITY · PI PARADIS, SUZANNE · 2010 to 2024
$5.4M
NINDS NIH HHS R01 NS065856
6 · The paper itself

Abstract

Synaptic plasticity, the process whereby neuronal connections are either strengthened or weakened in response to stereotyped forms of stimulation, is widely believed to represent the molecular mechanism that underlies learning and memory. The holoenzyme CaMKII plays a well-established and critical role in the induction of a variety of forms of synaptic plasticity such as long-term potentiation (LTP), long-term depression (LTD) and depotentiation. Previously, we identified the GTPase Rem2 as a potent, endogenous inhibitor of CaMKII. Here, we report that knock out of

Identifiers

PMID38558974
PMCPMC10979978
OpenAlexW4392697755

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.