Evidence map›Paper›PMID 38558969›Full record

ArticlebioRxiv : the preprint server for biology2024

Reactive microglia fail to respond to environmental damage signals in a viral-induced mouse model of temporal lobe epilepsy.

Glenna J Wallis, Laura A Bell, John N Wagner, Lauren Buxton, Lakshmini Balachandar, Karen S Wilcox

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Glenna J WallisDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 80904.ORCID 0000-0001-6001-8796
Laura A BellDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 80904.ORCID 0000-0003-0659-5650
John N WagnerDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 80904.
Lauren BuxtonDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 80904.
Lakshmini BalachandarDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 80904.ORCID 0000-0003-4795-7355
Karen S WilcoxDepartment of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 80904.ORCID 0000-0003-2660-8826
University of Utah · US

Funding

Role of microglia in a novel model of temporal lobe epilepsyR37NS065434 · NINDS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WILCOX, KAREN S · 2019 to 2025
$2.6M
Investigating the role of NG2-glia in the development of epilepsyF99NS125773 · NINDS · UNIVERSITY OF UTAH · PI BELL, LAURA ANN · 2021 to 2021
$41k
NINDS NIH HHS F99 NS125773NINDS NIH HHS R37 NS065434
6 · The paper itself

Abstract

Microglia are highly adaptable innate immune cells that rapidly respond to damage signals in the brain through adoption of a reactive phenotype and production of defensive inflammatory cytokines. Microglia express a distinct transcriptome, encoding receptors that allow them to dynamically respond to pathogens, damage signals, and cellular debris. Expression of one such receptor, the microglia-specific purinergic receptor

Indexed as

CalciumepilepsyGCaMPMicroglianeuroinflammationneuroscienceseizuresviral infection

Identifiers

PMID38558969
PMCPMC10979929
OpenAlexW4392694212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.