Evidence map›Paper›PMID 38558964›Full record

ArticlebioRxiv : the preprint server for biology2024

A Novel, Robust, and Portable Platform for Magnetoencephalography using Optically Pumped Magnetometers.

Holly Schofield, Ryan M Hill, Odile Feys, Niall Holmes, James Osborne, Cody Doyle, David Bobela, Pierre Corvilian, Vincent Wens, Lukas Rier and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 3 countries.

Holly SchofieldSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Ryan M HillSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Odile FeysUniversité libre de Bruxelles, ULB Neuroscience Institute, Laboratoire de neuroanatomie et neuroimagerie translationelles, Brussels, Belgium.ORCID 0000-0001-5014-4094
Niall HolmesSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
James OsborneQuSpin Inc. 331 South 104 Street, Suite 130, Louisville, Colorado, 80027, USA.
Cody DoyleQuSpin Inc. 331 South 104 Street, Suite 130, Louisville, Colorado, 80027, USA.
David BobelaQuSpin Inc. 331 South 104 Street, Suite 130, Louisville, Colorado, 80027, USA.
Pierre CorvilianUniversité libre de Bruxelles, ULB Neuroscience Institute, Laboratoire de neuroanatomie et neuroimagerie translationelles, Brussels, Belgium.
Vincent WensUniversité libre de Bruxelles, ULB Neuroscience Institute, Laboratoire de neuroanatomie et neuroimagerie translationelles, Brussels, Belgium.
Lukas RierSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.ORCID 0000-0002-4560-8787
Richard BowtellSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Maxime FerezUniversité libre de Bruxelles, ULB Neuroscience Institute, Laboratoire de neuroanatomie et neuroimagerie translationelles, Brussels, Belgium.
Karen J MullingerSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Sebastian ColemanSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Natalie RhodesSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Molly ReaCerca Magnetics Limited, 2 Castlebridge Office Village, Kirtley Drive, Nottingham, NG7 1LD, Nottingham, UK.
Zoe TannerSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Elena BotoCerca Magnetics Limited, 2 Castlebridge Office Village, Kirtley Drive, Nottingham, NG7 1LD, Nottingham, UK.
Xavier de TiègeUniversité libre de Bruxelles, ULB Neuroscience Institute, Laboratoire de neuroanatomie et neuroimagerie translationelles, Brussels, Belgium.
Vishal ShahQuSpin Inc. 331 South 104 Street, Suite 130, Louisville, Colorado, 80027, USA.
Matthew J BrookesSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
University of Nottingham · GBUniversité Libre de Bruxelles · BEQuSpin (United States) · US

Funding

High-resolution Non-cryogenic Magnetoencephalography: Systems-Level IntegrationR44MH110288 · NIMH · QUSPIN · PI SHAH, VISHAL K · 2016 to 2022
$5.1M
NIMH NIH HHS R44 MH110288
6 · The paper itself

Abstract

Magnetoencephalography (MEG) measures brain function via assessment of magnetic fields generated by neural currents. Conventional MEG uses superconducting sensors, which place significant limitations on performance, practicality, and deployment; however, the field has been revolutionised in recent years by the introduction of optically-pumped-magnetometers (OPMs). OPMs enable measurement of the MEG signal without cryogenics, and consequently the conception of 'OPM-MEG' systems which ostensibly allow increased sensitivity and resolution, lifespan compliance, free subject movement, and lower cost. However, OPM-MEG remains in its infancy with limitations on both sensor and system design. Here, we report a new OPM-MEG design with miniaturised and integrated electronic control, a high level of portability, and improved sensor dynamic range (arguably the biggest limitation of existing instrumentation). We show that this system produces equivalent measures when compared to an established instrument; specifically, when measuring task-induced beta-band, gamma-band and evoked neuro-electrical responses, source localisations from the two systems were highly comparable and temporal correlation was >0.7 at the individual level and >0.9 for groups. Using an electromagnetic phantom, we demonstrate improved dynamic range by running the system in background fields up to 8 nT. We show that the system is effective in gathering data during free movement (including a sitting-to-standing paradigm) and that it is compatible with simultaneous electroencephalography (EEG - the clinical standard). Finally, we demonstrate portability by moving the system between two laboratories. Overall, our new system is shown to be a significant step forward for OPM-MEG technology and offers an attractive platform for next generation functional medical imaging.

Indexed as

ElectrophysiologyMagnetoencephalographyMEGOPMOptically pumped magnetometer

Identifiers

PMID38558964
PMCPMC10979878
OpenAlexW4392725860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.