Evidence map›Paper›PMID 38558816›Full record

ReviewFrontiers in immunology2024

Role of Treg cell subsets in cardiovascular disease pathogenesis and potential therapeutic targets.

Yuanliang Xia, Di Gao, Xu Wang, Bin Liu, Xue Shan, Yunpeng Sun, Dashi Ma

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanliang XiaDepartment of Cardiac Surgery, The First Hospital of Jilin University, Changchun, China.
Di GaoDepartment of Cardiac Surgery, The First Hospital of Jilin University, Changchun, China.
Xu WangDepartment of Cardiac Surgery, The First Hospital of Jilin University, Changchun, China.
Bin LiuDepartment of Cardiac Surgery, The First Hospital of Jilin University, Changchun, China.
Xue ShanDepartment of Cardiac Surgery, The First Hospital of Jilin University, Changchun, China.
Yunpeng SunDepartment of Cardiac Surgery, The First Hospital of Jilin University, Changchun, China.
Dashi MaDepartment of Cardiac Surgery, The First Hospital of Jilin University, Changchun, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the genesis and progression of cardiovascular diseases involving both innate and adaptive immune responses, inflammation plays a pivotal and dual role. Studies in experimental animals indicate that certain immune responses are protective, while others exacerbate the disease. T-helper (Th) 1 cell immune responses are recognized as key drivers of inflammatory progression in cardiovascular diseases. Consequently, the CD4+CD25+FOXP3+ regulatory T cells (Tregs) are gaining increasing attention for their roles in inflammation and immune regulation. Given the critical role of Tregs in maintaining immune-inflammatory balance and homeostasis, abnormalities in their generation or function might lead to aberrant immune responses, thereby initiating pathological changes. Numerous preclinical studies and clinical trials have unveiled the central role of Tregs in cardiovascular diseases, such as atherosclerosis. Here, we review the roles and mechanisms of Treg subsets in cardiovascular conditions like atherosclerosis, hypertension, myocardial infarction and remodeling, myocarditis, dilated cardiomyopathy, and heart failure. While the precise molecular mechanisms of Tregs in cardiac protection remain elusive, therapeutic strategies targeting Tregs present a promising new direction for the prevention and treatment of cardiovascular diseases.

Indexed as

AtherosclerosisCardiovascular DiseasesMyocardial InfarctionAnimalsInflammationT-Lymphocytes, Regulatoryatherosclerosiscardiovascular diseasehypertensionimmune microenvironmentimmunotherapyTreg cell

Identifiers

PMID38558816
PMCPMC10978666

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.