Evidence map›Paper›PMID 38558527›Full record

ArticleDiabetes, obesity & metabolism2024

Differential effect of endogenous glucagon-like peptide-1 on prandial glucose counterregulatory response to hypoglycaemia in humans with and without bariatric surgery.

Henri Honka, Amalia Gastaldelli, Samantha Pezzica, Richard Peterson, Ralph DeFronzo, Marzieh Salehi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, obesity & metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Henri HonkaDivision of Diabetes, University of Texas Health Science Center, San Antonio, Texas, USA.ORCID 0000-0003-1389-6355
Amalia GastaldelliCardiometabolic Risk Unit, Institute of Clinical Physiology-National Research Council, Pisa, Italy.ORCID 0000-0003-2594-1651
Samantha PezzicaCardiometabolic Risk Unit, Institute of Clinical Physiology-National Research Council, Pisa, Italy.
Richard PetersonDepartment of Surgery, University of Texas Health Science Center, San Antonio, Texas, USA.
Ralph DeFronzoDivision of Diabetes, University of Texas Health Science Center, San Antonio, Texas, USA.ORCID 0000-0002-8581-6273
Marzieh SalehiDivision of Diabetes, University of Texas Health Science Center, San Antonio, Texas, USA.
The University of Texas Health Science Center at San Antonio · USIstituto di Fisiologia Clinica · IT

Funding

Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR002645 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2018 to 2022
$20.4M
The Weight-Independent Effects of Bariatric Surgeries on Islet Cell FunctionR01DK105379 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SALEHI, MARZIEH · 2015 to 2020
$2.4M
NCATS NIH HHS TR002645NIDDK NIH HHS DK105379NIDDK NIH HHS R01 DK105379
6 · The paper itself

Abstract

aimTo determine the effect of endogenous glucagon-like peptide 1 (GLP-1) on prandial counterregulatory response to hypoglycaemia after gastric bypass (GB). MATERIALS AND

methodsGlucose fluxes, and islet-cell and gut hormone responses before and after mixed-meal ingestion, were compared during a hyperinsulinaemic-hypoglycaemic (~3.2 mmol/L) clamp with and without a GLP-1 receptor (GLP-1R) antagonist exendin-(9-39) infusion in non-diabetic patients who had previously undergone GB compared to matched participants who had previously undergone sleeve gastrectomy (SG) and non-surgical controls.

resultsExendin-(9-39) infusion raised prandial endogenous glucose production (EGP) response to insulin-induced hypoglycaemia in the GB group but had no consistent effect on EGP response among the SG group or non-surgical controls (p < 0.05 for interaction). The rates of systemic appearance of ingested glucose or prandial glucose utilization did not differ among the three groups or between studies with and without exendin-(9-39) infusion. Blockade of GLP-1R had no effect on insulin secretion or insulin action but enhanced prandial glucagon in all three groups.

conclusionsThese results indicate that impaired post-meal glucose counterregulatory response to hypoglycaemia after GB is partly mediated by endogenous GLP-1, highlighting a novel pathogenic mechanism of GLP-1 in developing hypoglycaemia in this population.

Indexed as

Blood GlucoseGastric BypassGlucagon-Like Peptide 1HypoglycemiaAdultFemaleGastrectomyGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsGlucose Clamp TechniqueHumansInsulinMaleMiddle AgedPeptide FragmentsPostprandial PeriodBlood Glucoseexendin (9-39)Glucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsInsulinPeptide Fragmentscounterregulatory responsegastric bypassglucagon‐like peptide 1hypoglycaemia

Identifiers

PMID38558527
PMCPMC11078606
OpenAlexW4393391795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.