Evidence map›Paper›PMID 38558367›Full record

ArticleMarine biotechnology (New York, N.Y.)2024

Production of Antioxidant, Angiotensin-Converting Enzyme Inhibitory and Osteogenic Gelatin Hydrolysate from Labeo rohita Swim Bladder.

Balaji Wamanrao Kanwate, Kalpana Patel, Sandesh Suresh Karkal, Deependra Rajoriya, Kunal Sharan, Tanaji G Kudre

Abstract read
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In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Balaji Wamanrao KanwateDepartment of Meat and Marine Sciences, CSIR-Central Food Technological Research Institute, Mysuru-570 020, Karnataka, India.
Kalpana PatelDepartment of Molecular Nutrition, CSIR-Central Food Technological Research Institute, Mysuru-570 020, Karnataka, India.
Sandesh Suresh KarkalDepartment of Meat and Marine Sciences, CSIR-Central Food Technological Research Institute, Mysuru-570 020, Karnataka, India.
Deependra RajoriyaFood Engineering Department, CSIR-Central Food Technological Research Institute, Mysuru-570 020, Karnataka, India.
Kunal SharanDepartment of Molecular Nutrition, CSIR-Central Food Technological Research Institute, Mysuru-570 020, Karnataka, India.
Tanaji G KudreDepartment of Meat and Marine Sciences, CSIR-Central Food Technological Research Institute, Mysuru-570 020, Karnataka, India. tkudre@cftri.res.in.
Central Food Technological Research Institute · INAcademy of Scientific and Innovative Research · IN

Funding

Science and Engineering Research Board ECR/2015/000215
6 · The paper itself

Abstract

Optimization of antioxidants and angiotensin-converting enzyme (ACE) inhibitory potential gelatin hydrolysate production from Labeo rohita (rohu) swim bladder (SBGH) by alcalase using central composite design (CCD) of response surface methodology (RSM) was investigated. The maximum degree of hydrolysis (DH), 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), total antioxidants (TAO), and ACE inhibitory activity were achieved at 0.1:1.0 (w/w) enzyme to substrate ratio, 61 °C hydrolysis temperature, and 94-min hydrolysis time. The resulting SBGH obtained at 19.92% DH exhibited the DPPH (24.28 µM TE/mg protein), ABTS (34.47 µM TE/mg protein), TAO (12.01 µg AAE/mg protein), and ACE inhibitory (4.91 µg/mg protein) activity. Furthermore, SBGH at 100 µg/ml displayed osteogenic property without any toxic effects on MC3T3-E1 cells. Besides, the protein content of rohu swim bladder gelatin (SBG) and SBGH was 93.68% and 94.98%, respectively. Both SBG and SBGH were rich in glycine, proline, glutamic acid, alanine, arginine, and hydroxyproline amino acids. Therefore, SBGH could be an effective nutraceutical in functional food development.

Indexed as

Air SacsFishesAngiotensin-Converting Enzyme InhibitorsAnimalsAntioxidantsBiphenyl CompoundsCyprinidaeFish ProteinsGelatinHydrolysisOsteogenesisPicratesProtein HydrolysatesSubtilisins1,1-diphenyl-2-picrylhydrazylAngiotensin-Converting Enzyme InhibitorsAntioxidantsBiphenyl CompoundsFish ProteinsGelatinPicratesProtein HydrolysatesSubtilisinsACE inhibitory activityAntioxidant activityGelatin hydrolysateOsteogenic propertyResponse surface methodologyRohu swim bladder

Identifiers

PMID38558367
OpenAlexW4393387021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.