Evidence map›Paper›PMID 38558027›Full record

ArticleDie Naturwissenschaften2024

The protective effects of Zingiber zerumbet rhizome against fevers in rats.

Haslinda Mohd Salleh, Abdulwali Ablat, Soon-Lim Chong, Hazrina Hazni, Norsita Tohar, Nurulwahidah Fauzi, Habibah A Wahab, Muhamad Aqmal Othman, Sook Yee Liew, Khalijah Awang

Abstract read
PubMed Publisher
In one paragraph

Article in Die Naturwissenschaften, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Haslinda Mohd SallehDepartment of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Abdulwali AblatDepartment of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Soon-Lim ChongDepartment of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Hazrina HazniCentre for Natural Products Research and Drug Discovery (CENAR), Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Norsita ToharDepartment of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Nurulwahidah FauziFaculty of Quranic and Sunnah Studies, Universiti Sains Islam Malaysia, Negeri Sembilan, 71800, Nilai, Malaysia.
Habibah A WahabSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.
Muhamad Aqmal OthmanDepartment of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Sook Yee LiewCentre for Natural Products Research and Drug Discovery (CENAR), Universiti Malaya, 50603, Kuala Lumpur, Malaysia. joeyliew5382@um.edu.my.
Khalijah AwangDepartment of Chemistry, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. khalijah@um.edu.my.ORCID http://orcid.org/0000-0001-5971-6570
University of Malaya · MYUniversiti Sains Islam Malaysia · MYUniversiti Sains Malaysia · MY

Funding

Institut Pengurusan dan Pemantauan Penyelidikan, Universiti Malaya PG101-2016AMinistry of Education (MY) TRGS/1/2014/UM/01/2/2Universiti Sains Islam Malaysia PPP/UCG-0116/FPQS/30/14316
6 · The paper itself

Abstract

The Zingiber zerumbet rhizomes are traditionally used to treat fever, and the in vitro inhibitory effect of ethyl acetate extract from Zingiber zerumbet rhizomes (EAEZZR) against DENV2 NS2B/NS3 (two non-structural proteins, NS2 and NS3 of dengue virus type 2) has been reported earlier. This study was carried out to establish an acute toxicity profile and evaluate the anti-fever (anti-pyretic) activities of EAEZZR in yeast-induced fever in rats. The major compound of EAEZZR, zerumbone, was isolated using chromatographic methods including column chromatography (CC) and preparative thin-layer chromatography (PTLC). Additionally, the structure of zerumbone was elucidated using nuclear magnetic resonance (NMR), liquid chromatography mass spectrometer-ion trap-time of flight (LCMS-IT-TOF), infrared (IR), and ultraviolet (UV) spectroscopy. The toxicity of EAEZZR was evaluated using Organization for Economic Cooperation and Development Test Guideline 425 (OECD tg-425) with minor modifications at concentrations EAEZZR of 2000 mg/kg, 3000 mg/kg, and 5000 mg/kg. Anti-fever effect was determined by yeast-induced fever (pyrexia) in rats. The acute toxicity study showed that EAEZZR is safe at the highest 5000 mg/kg body weight dose in Sprague Dawley rats. Rats treated with EAEZZR at doses of 125, 250, and 500 mg/kg exhibited a significant reduction in rectal temperature (T

Indexed as

AcetatesPlant ExtractsRhizomeSesquiterpenesAnimalsFeverRatsRats, Sprague-DawleySaccharomyces cerevisiaeAcetatesethyl acetatePlant ExtractsSesquiterpeneszerumboneAnti-pyreticFeverSprague DawleyToxicityZerumboneZingiberaceae

Identifiers

PMID38558027
OpenAlexW4393381441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.