Evidence map›Paper›PMID 38557933›Full record

ArticleCancer causes & control : CCC2024

Effects of hypertension and use of antihypertensive drugs in pregnancy on the risks of childhood cancers in Taiwan.

Helen T Orimoloye, Ya-Hui Hu, Noah Federman, Beate Ritz, Onyebuchi A Arah, Chung-Yi Li, Pei-Chen Lee, Julia E Heck

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Helen T OrimoloyeCollege of Health and Public Service, University of North Texas, Denton, TX, USA.
Ya-Hui HuDepartment of Public Health, College of Medicine, National Cheng Kung University, No. 1, University Road, Tainan, 70101, Taiwan.
Noah FedermanDepartment of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Onyebuchi A ArahDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Chung-Yi LiDepartment of Public Health, College of Medicine, National Cheng Kung University, No. 1, University Road, Tainan, 70101, Taiwan.
Pei-Chen LeeDepartment of Public Health, College of Medicine, National Cheng Kung University, No. 1, University Road, Tainan, 70101, Taiwan. peichenlee@gs.ncku.edu.tw.
Julia E HeckCollege of Health and Public Service, University of North Texas, Denton, TX, USA.
University of California, Los Angeles · USNational Cheng Kung University · TWMinistry of Health and Welfare · TWUniversity of North Texas · US

Funding

Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Martha Jane Bailey · 2016 to 2026
$6.9M
Maternal acetaminophen use and childhood cancerR03CA273608 · NCI · UNIVERSITY OF NORTH TEXAS · PI HECK, JULIA · 2022 to 2023
$159k
Alex's Lemonade Stand 17-01882National Science and Technology Council 112-2314-B-006 -068 -MY3NCI NIH HHS R03 CA273608NICHD NIH HHS P2C HD041022NIH HHS R03CA273608
6 · The paper itself

Abstract

backgroundChildhood cancers are associated with high mortality and morbidity, and some maternal prescription drug use during pregnancy has been implicated in cancer risk. There are few studies on the effects of hypertension, preeclampsia, and the use of antihypertensives in pregnancy on children's cancer risks.

objectiveThis population-based cohort study analyzed the relationship between hypertension, preeclampsia, and antihypertensives taken during pregnancy and the risks of childhood cancers in the offspring.

methodsData on all children born in Taiwan between 2004 and 2015 (N = 2,294,292) were obtained from the Maternal and Child Health Database. This registry was linked with the National Health Insurance Database and Cancer Registry to get the records of maternal use of diuretics or other antihypertensives in pregnancy and records of children with cancer diagnosed before 13 years. We used Cox proportional hazard modeling to estimate the influence of maternal health conditions and antihypertensive drug exposure on the risks of developing childhood cancers.

resultsOffspring of mothers with hypertension (chronic or gestational) had a higher risk of acute lymphocytic lymphoma [hazard ratio (HR) = 1.87, 95% Confidence Interval (CI) 1.32 - 2.65] and non-Hodgkin's lymphoma (HR = 1.96, 95% CI 1.34 - 2.86). We estimated only a weak increased cancer risk in children whose mothers used diuretics (HR = 1.16, 95% CI 0.77 - 1.74) or used antihypertensives other than diuretics (HR = 1.15, 95% CI 0.86 - 1.54) before birth.

conclusionsIn this cohort study, children whose mothers had chronic and gestational hypertension had an increased risk of developing childhood cancer.

Indexed as

Antihypertensive AgentsHypertensionNeoplasmsPrenatal Exposure Delayed EffectsAdolescentAdultChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornMalePregnancyRegistriesAntihypertensive AgentsAntihypertensivesChildhood cancer epidemiologyDiureticsGestational hypertensionPreeclampsia

Identifiers

PMID38557933
PMCPMC11520249
OpenAlexW4393376215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.