Evidence map›Paper›PMID 38557927›Full record

ArticleJournal of neuro-oncology2024

Loss of methylthioadenosine phosphorylase immunoreactivity correlates with poor prognosis and elevated uptake of

Toshihiro Yamamura, Kaoru Tamura, Daisuke Kobayashi, Motoki Inaji, Yuka Toyama, Hiroaki Wakimoto, Juri Kiyokawa, Shoko Hara, Yoji Tanaka, Tadashi Nariai and 3 more

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Current and emerging therapies in IDH-mutant glioma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  4. Prognostic implication ofNeuro-oncology advances
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Toshihiro YamamuraDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Kaoru TamuraDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan. tamura.nsrg@tmd.ac.jp.ORCID http://orcid.org/0000-0002-7943-5458
Daisuke KobayashiDepartment of Human Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Motoki InajiDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Yuka ToyamaDepartment of Human Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Hiroaki WakimotoDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge St, Boston, MA, 02114, USA.
Juri KiyokawaDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Shoko HaraDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Yoji TanakaDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Tadashi NariaiDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Kazuhide ShimizuDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Kenji IshiiResearch Team for Neuroimaging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakaecho, Itabashi-Ku, Tokyo, 173-0015, Japan.
Taketoshi MaeharaDepartment of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Tokyo Medical and Dental University · JPHarvard University · USTokyo Metropolitan Institute of Gerontology · JP

Funding

Japan Society for the Promotion of Science 20K09321
6 · The paper itself

Abstract

purposeThe proximate localization of MTAP, which encodes methylthioadenosine phosphorylase, and CDKN2A/B on Chromosome 9q21 has allowed the loss of MTAP expression as a surrogate for homozygous deletion of CDKN2A/B. This study aimed to determine whether MTAP status correlates with clinical outcomes and

methodsWe conducted immunohistochemistry for MTAP in 30 patients with astrocytoma, IDH-mutant who underwent

resultsAmong IDH-mutant astrocytomas, 26.7% (8/30) exhibited the loss of cytoplasmic MTAP expression, whereas 73.3% (22/30) tumors retained MTAP expression. The median progression-free survival (PFS) was significantly shorter in patients with MTAP loss than those with MTAP retention (1.88 years vs. 6.80 years, p = 0.003). The median overall survival (OS) was also shorter in patients with MTAP loss than in MTAP-retaining counterparts (5.23 years vs. 10.69 years, p = 0.019). Multivariate analysis identified MTAP status (hazard ratio (HR), 0.081) and extent of resection (HR, 0.104) as independent prognostic factors for PFS. Astrocytomas lacking cytoplasmic MTAP expression showed a significantly higher median T/N ratio for

conclusionOur study revealed that the loss of MTAP expression correlates with poor prognosis and an elevated T/N ratio of

Indexed as

AstrocytomaBrain NeoplasmsIsocitrate DehydrogenaseMethionineMutationPurine-Nucleoside PhosphorylaseAdultAgedBiomarkers, TumorCarbon RadioisotopesFemaleHumansMaleMiddle AgedPositron-Emission TomographyPrognosis5'-methylthioadenosine phosphorylaseBiomarkers, TumorCarbon RadioisotopesIsocitrate DehydrogenaseMethioninePurine-Nucleoside Phosphorylase11C-methionine positron emission tomographyAstrocytomaCDKN2A/BIDH-mutantMTAP

Identifiers

PMID38557927
OpenAlexW4393377827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.