Evidence map›Paper›PMID 38557789›Full record

ArticleMolecular and cellular biochemistry2025

Protein kinase D2-Aurora kinase A-ERK1/2 signalling axis drives neuroendocrine differentiation of epithelial ovarian cancer.

Abha Sachdeva, Adhiraj Roy, Supratim Mandal

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Abha SachdevaAmity Institute of Molecular Medicine and Stem Cell Research, Amity University, Sector 125, Noida, Uttar Pradesh, 201303, India.
Adhiraj RoyAmity Institute of Molecular Medicine and Stem Cell Research, Amity University, Sector 125, Noida, Uttar Pradesh, 201303, India. aroy2@amity.edu.
Supratim MandalDepartment of Microbiology, University of Kalyani, Kalyani, Nadia, West Bengal, 741235, India.
Institute of Molecular Medicine · INUniversity of Kalyani · IN

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/HRD/35/02/2006
6 · The paper itself

Abstract

Epithelial ovarian cancer (EOC) is deadliest gynecological malignancy with poor prognosis and patient survival. Despite development of several therapeutic interventions such as poly-ADP ribose polymerase (PARP) inhibitors, EOC remains unmanageable and discovery of novel early detection biomarkers and treatment targets are highly warranted. Although neuroendocrine differentiation (NED) is implicated in different human cancers including prostate adenocarcinoma and lung cancer, mechanistic studies concerning NED of epithelial ovarian cancer are lacking. We report that Aurora kinase A drives NED of epithelial ovarian cancer in an ERK1/2-dependent manner and pharmacological and genetic inhibition of Aurora kinase A suppress NED of ovarian cancer. Moreover, we demonstrate that protein kinase D2 positively regulated Aurora kinase A to drive NED. Overexpression of catalytically active PKD2 drives NED and collectively, PKD2 cross talks with Aurora kinase A/ERK1/2 signalling axis to positively regulate NED of EOC. PKD2/Aurora kinase A/ERK1/2 signalling axis is a novel therapeutic target against neuroendocrine differentiated EOC.

Indexed as

Aurora Kinase ACarcinoma, Ovarian EpithelialCell DifferentiationMAP Kinase Signaling SystemOvarian NeoplasmsProtein Kinase D2Cell Line, TumorFemaleHumansMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3TRPP Cation ChannelsAURKA protein, humanAurora Kinase AMAPK1 protein, humanMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Protein Kinase D2TRPP Cation ChannelsAurora kinase ACancer cell signallingChemoresistanceEpithelial ovarian cancerNeuroendocrine differentiationProtein kinase D2

Identifiers

PMID38557789
OpenAlexW4393386821

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.