Evidence map›Paper›PMID 38557377›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2024

[Screening for Duchenne muscular dystrophy in newborns in the Ningxia region].

Miao Jing, Yue Wang, Xiao-Ying Jing, Xin-Mei Mao

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Progress and Prospects of Newborn Screening in China.International journal of neonatal screening · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Miao JingDepartment of Inherited Metabolic Diseases, Peking University First Hospital Ningxia Women and Children's Hospital/Ningxia Hui Autonomous Region Maternal and Child Health Hospital, Yinchuan 750002, China.
Yue WangDepartment of Inherited Metabolic Diseases, Peking University First Hospital Ningxia Women and Children's Hospital/Ningxia Hui Autonomous Region Maternal and Child Health Hospital, Yinchuan 750002, China.
Xiao-Ying JingDepartment of Inherited Metabolic Diseases, Peking University First Hospital Ningxia Women and Children's Hospital/Ningxia Hui Autonomous Region Maternal and Child Health Hospital, Yinchuan 750002, China.
Xin-Mei MaoDepartment of Inherited Metabolic Diseases, Peking University First Hospital Ningxia Women and Children's Hospital/Ningxia Hui Autonomous Region Maternal and Child Health Hospital, Yinchuan 750002, China.
The Fourth People's Hospital of Ningxia Hui Autonomous Region · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the incidence rate of Duchenne muscular dystrophy (DMD) in the male newborns in the Ningxia region and establish a critical threshold for screening DMD in newborns to distinguish between the normal population and affected individuals.

methodsA total of 10 000 male newborns were screened using immunofluorescence analysis of creatine kinase isoenzyme concentrations in heel spot dried blood specimens. Newborns with the concentrations higher than the critical threshold were recalled for serum creatine kinase measurements. Genetic testing was performed to confirm diagnosis in cases showing abnormalities.

resultsAmong the screened 10 000 male newborns, two were confirmed to have DMD through genetic testing, resulting in a preliminary estimated incidence rate of 1/5 000 for male newborns in the Ningxia region. The critical threshold for creatine kinase isoenzyme concentration in newborns in this region was determined to be 468.57 ng/mL.

conclusionsScreening for DMD in newborns is feasible in the Ningxia region. Early screening, diagnosis, and treatment of DMD can improve the quality of life for affected individuals and help families make informed decisions regarding further pregnancies.

Indexed as

Muscular Dystrophy, DuchenneCreatine KinaseHumansInfant, NewbornIsoenzymesMaleNeonatal ScreeningQuality of LifeCreatine KinaseIsoenzymesCreatine kinase isoenzymeCritical thresholdDuchenne muscular dystrophyIncidence rateNewbornScreening

Identifiers

PMID38557377
PMCPMC10986384
OpenAlexW4394741383

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.