Evidence map›Paper›PMID 38557355›Full record

ArticleAmerican journal of physiology. Cell physiology2024

A digoxin derivative that potently reduces intraocular pressure: efficacy and mechanism of action in different animal models.

Veluchamy Amutha Barathi, Adriana Katz, Shashikant Chaudhary, Hoi-Lam Li, Daniel M Tal, Arie Marcovich, Chi-Wai Do, Steven J D Karlish

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Veluchamy Amutha BarathiTranslational Pre-Clinical Model Platform, Singapore Institute of Eye Research (SERI).ORCID 0000-0002-6477-9784
Adriana KatzDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Shashikant ChaudharySchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.
Hoi-Lam LiSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.
Daniel M TalDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Arie MarcovichOpthalmology Department, Kaplan Medical Center, Rehovot, Israel.
Chi-Wai DoSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.ORCID 0000-0002-7720-7507
Steven J D KarlishDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-7399-9279
Hong Kong Polytechnic University · HKWeizmann Institute of Science · ILHebrew University of Jerusalem · ILNational University of Singapore · SG

Funding

Health and Mecial Research Fund, 20212781InnoHK 1-CD65Les and Cyndy Lederer Fund; Weizmann Institute NAYeda Corporation, Weizmann Institute of Science NA
6 · The paper itself

Abstract

Glaucoma is a blinding disease. Reduction of intraocular pressure (IOP) is the mainstay of treatment, but current drugs show side effects or become progressively ineffective, highlighting the need for novel compounds. We have synthesized a family of perhydro-1,4-oxazepine derivatives of digoxin, the selective inhibitor of Na,K-ATPase. The cyclobutyl derivative (DcB) displays strong selectivity for the human α2 isoform and potently reduces IOP in rabbits. These observations appeared consistent with a hypothesis that in ciliary epithelium DcB inhibits the α2 isoform of Na,K-ATPase, which is expressed strongly in nonpigmented cells, reducing aqueous humor (AH) inflow. This paper extends assessment of efficacy and mechanism of action of DcB using an ocular hypertensive nonhuman primate model (OHT-NHP) (

Indexed as

Aqueous HumorDigoxinIntraocular PressureMacaca fascicularisOcular HypertensionAnimalsCiliary BodyDisease Models, AnimalGlaucomaHumansMaleRabbitsSodium-Potassium-Exchanging ATPaseTrabecular MeshworkDigoxinSodium-Potassium-Exchanging ATPasedigoxin derivativeintraocular pressureNa,K-ATPase

Identifiers

PMID38557355
PMCPMC11371363
OpenAlexW4393382479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.