Evidence map›Paper›PMID 38557323›Full record

ArticleBlood transfusion = Trasfusione del sangue2024

Genomic characterization of clinically significant blood group variants in Aboriginal Australians.

Sudhir Jadhao, Candice Davison, Eileen Roulis, Simon Lee, Tamika Campbell, Reece Griffin, Maree Toombs, Alex Brown, Maree Perry, Bushra Nasir and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood transfusion = Trasfusione del sangue, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Sudhir JadhaoCentre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, Australia.
Candice DavisonResearch and Development, Australian Red Cross Lifeblood, Kelvin Grove, Australia.
Eileen RoulisResearch and Development, Australian Red Cross Lifeblood, Kelvin Grove, Australia.
Simon LeeCentre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, Australia.
Tamika CampbellCarbal Medical Services, Toowoomba, Australia.
Reece GriffinCarbal Medical Services, Toowoomba, Australia.
Maree ToombsSchool of Population Health, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
Alex BrownNational Centre for Indigenous Genomics, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Maree PerryResearch and Development, Australian Red Cross Lifeblood, Kelvin Grove, Australia.
Bushra NasirRural Clinical School, Faculty of Medicine, The University of Queensland, Toowoomba, Australia.
David O IrvingResearch and Development, Australian Red Cross Lifeblood, Kelvin Grove, Australia.
Catherine A HylandResearch and Development, Australian Red Cross Lifeblood, Kelvin Grove, Australia.
Robert L FlowerResearch and Development, Australian Red Cross Lifeblood, Kelvin Grove, Australia.
Shivashankar H NagarajCentre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, Australia.
Australian Red Cross Lifeblood · AUQueensland University of Technology · AUThe Kids Research Institute Australia · AUUniversity of Queensland · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHematological disorders are often treated with blood transfusions. Many blood group antigens and variants are population-specific, and for patients with rare blood types, extensive donor screening is required to find suitable matches for transfusion. There is a scarcity of knowledge regarding blood group variants in Aboriginal Australian populations, despite a higher need for transfusion due to the higher prevalence of renal diseases and anemia. MATERIALS AND

methodsIn this study, we applied next-generation sequencing and analysis to 245 samples obtained from Aboriginal Australians from South-East Queensland, to predict antigen phenotypes for 36 blood group systems.

resultsWe report potential weak antigens in blood group systems RH, FY and JR that have potential clinical implications in transfusion and pregnancy settings. These include partial DIII type 4, weak D type 33, and Del RHD (IVS2-2delA). The rare Rh phenotypes D+ C+ E+ c- e+ and D+ C+ E+ c+ e- were also detected. DISCUSSION: The comprehensive analyses of blood group genetic variant profiles identified in this study will provide insight and an opportunity to improve Aboriginal health by aiding in the identification of appropriate blood products for population-specific transfusion needs.

Indexed as

Australian Aboriginal and Torres Strait Islander PeoplesBlood Group AntigensAustraliaFemaleGenetic VariationHigh-Throughput Nucleotide SequencingHumansMalePregnancyRh-Hr Blood-Group SystemBlood Group AntigensRh-Hr Blood-Group System

Identifiers

PMID38557323
PMCPMC11576151
OpenAlexW4394759312

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.