Evidence map›Paper›PMID 38557107›Full record

ArticleOrganic letters2024

Function-Oriented Synthesis of Pentacyclic Triterpenoids and Discovery of an

Zachary D Stempel, Hanna S Radomska, Christopher C Coss, Glenn C Micalizio

Open access · greenAbstract read
In one paragraph

Article in Organic letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zachary D StempelDepartment of Chemistry, Dartmouth College, Burke Laboratory, Hanover, New Hampshire 03755, United States.
Hanna S RadomskaDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
Christopher C CossDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-8184-9190
Glenn C MicalizioDepartment of Chemistry, Dartmouth College, Burke Laboratory, Hanover, New Hampshire 03755, United States.ORCID 0000-0002-3408-5570
Dartmouth College · USThe Ohio State University · US

Funding

Metallacycle-mediated coupling in stereoselective synthesisR35GM134725 · NIGMS · DARTMOUTH COLLEGE · PI MICALIZIO, GLENN C · 2020 to 2024
$2.6M
NIGMS NIH HHS R35 GM134725
6 · The paper itself

Abstract

While pentacyclic triterpenoids have a rich history in chemistry and biology, the challenges associated with their asymmetric synthesis contribute to the current reality that medicinal exploration in the area is largely constrained to natural product derivatization. To address this deficiency, a function-oriented synthesis of pentacyclic triterpenoids was pursued. Overall, we report a divergent synthesis of 26-norgermanicol and 26-norlupeol and we have identified a new class of androgen receptor antagonist that is ∼6× more potent than lupeol.

Indexed as

Biological ProductsTriterpenesAndrogen Receptor AntagonistsPentacyclic TriterpenesAndrogen Receptor AntagonistsBiological ProductsPentacyclic TriterpenesTriterpenes

Identifiers

PMID38557107
PMCPMC11590179
OpenAlexW4393374205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.