Evidence map›Paper›PMID 38557024›Full record

ArticleJournal of the American Chemical Society2024

Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain.

Wei-Li Lee, Xavier Westergaard, Christopher Hwu, Jennifer Hwu, Tomas Fiala, Clay Lacefield, Umed Boltaev, Adriana M Mendieta, Lisa Lin, Mark S Sonders and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Wei-Li LeeDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Xavier WestergaardDepartment of Biological Sciences, Columbia University, New York, New York 10027, United States.
Christopher HwuDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Jennifer HwuDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Tomas FialaDepartment of Chemistry, Columbia University, New York, New York 10027, United States.ORCID 0000-0001-6949-4561
Clay LacefieldDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Umed BoltaevDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Adriana M MendietaDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Lisa LinDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Mark S SondersDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Keaon R BrownDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Keer HeDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Wesley B AsherDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.
Jonathan A JavitchDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.ORCID 0000-0001-7395-2967
David SulzerDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.ORCID 0000-0001-7632-0439
Dalibor SamesDepartment of Chemistry, Columbia University, New York, New York 10027, United States.ORCID 0000-0001-6911-2260
Columbia University · USColumbia University Irving Medical Center · USETH Zurich · CH

Funding

The Dopamine Synapse and Associative LearningR01DA007418 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David Sulzer · 1999 to 2026
$9.4M
Development of Fluorescent False NeurotransmittersR01MH108186 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SAMES, DALIBOR, SULZER, DAVID · 2015 to 2024
$5.8M
NIDA NIH HHS R01 DA007418NIMH NIH HHS R01 MH108186
6 · The paper itself

Abstract

The serotonergic transmitter system plays fundamental roles in the nervous system in neurotransmission, synaptic plasticity, pathological processes, and therapeutic effects of antidepressants and psychedelics, as well as in the gastrointestinal and circulatory systems. We introduce a novel small molecule fluorescent agent, termed

Indexed as

Fluorescent DyesSerotoninAnimalsBrainMammalsNeuronsSerotonin Plasma Membrane Transport ProteinsFluorescent DyesSerotoninSerotonin Plasma Membrane Transport Proteins

Identifiers

PMID38557024
PMCPMC12781097
OpenAlexW4393377680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.