Evidence map›Paper›PMID 38556572›Full record

ArticleJournal of endocrinological investigation2024

Analysis of circulating osteoclast and osteogenic precursors in patients with Gorham-Stout disease.

M Rossi, S Terreri, G Battafarano, I Rana, P S Buonuomo, L Di Giuseppe, M D'Agostini, O Porzio, J Di Gregorio, Cristiana Cipriani and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

M RossiBone Physiopathology Research Unit, Translational Pediatrics and Clinical Genetics Research Division, Bambino Gesù Children's Hospital, IRCCS, Viale San Paolo 15, 00146, Rome, Italy.
S TerreriBone Physiopathology Research Unit, Translational Pediatrics and Clinical Genetics Research Division, Bambino Gesù Children's Hospital, IRCCS, Viale San Paolo 15, 00146, Rome, Italy.
G BattafaranoBone Physiopathology Research Unit, Translational Pediatrics and Clinical Genetics Research Division, Bambino Gesù Children's Hospital, IRCCS, Viale San Paolo 15, 00146, Rome, Italy.
I RanaRare Diseases and Medical Genetic Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
P S BuonuomoRare Diseases and Medical Genetic Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
L Di GiuseppeDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University, Rome, Italy.
M D'AgostiniClinical Laboratory, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
O PorzioClinical Laboratory, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
J Di GregorioDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Cristiana CiprianiDepartment of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University, Rome, Italy.
A JenknerPediatric Palliative Care Center, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
M V GonfiantiniRare Diseases and Medical Genetic Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
A BartuliRare Diseases and Medical Genetic Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
A Del FattoreBone Physiopathology Research Unit, Translational Pediatrics and Clinical Genetics Research Division, Bambino Gesù Children's Hospital, IRCCS, Viale San Paolo 15, 00146, Rome, Italy. andrea.delfattore@opbg.net.
Bambino Gesù Children's Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITSapienza University of Rome · ITUniversity of L'Aquila · ITUniversity of Rome Tor Vergata · IT

Funding

REHABILITATION TRAINING PRODUCTS FOR HOME HEALTH AIDESR43AG019116 · NIA · COMMUNICATION CONCEPTS AND CONSULTING · PI BETROS, CECIL G · 2001 to 2001
$100k
Ministero della Salute GR-2019-12370244Orphan Disease Center, Perelman School of Medicine, University of Pennsylvania MDBR-19-116-LGDA/LMIOrphan Disease Center, Perelman School of Medicine, University of Pennsylvania MDBR-21-111-LGDA/LMI
6 · The paper itself

Abstract

purposeGorham-Stout disease is a very rare disorder characterized by progressive bone erosion and angiomatous proliferation; its etiopathogenesis is still unknown, and diagnosis is still performed by exclusion criteria. The alteration of bone remodeling activity has been reported in patients; in this study, we characterized circulating osteoclast and osteogenic precursors that could be important to better understand the osteolysis observed in patients.

methodsFlow cytometry analysis of PBMC (Peripheral Blood Mononuclear Cells) was performed to characterize circulating osteoclast and osteogenic precursors in GSD patients (n = 9) compared to healthy donors (n = 55). Moreover, ELISA assays were assessed to evaluate serum levels of bone markers including RANK-L (Receptor activator of NF-κB ligand), OPG (Osteoprotegerin), BALP (Bone Alkaline Phosphatase) and OCN (Osteocalcin).

resultsWe found an increase of CD16

conclusionThe analysis of circulating bone cell precursors, as well as of RANK-L, could be relevant as an additional diagnostic tool for these patients and could be exploited for therapeutic purposes.

Indexed as

OsteoclastsOsteogenesisOsteolysis, EssentialAdolescentAdultAlkaline PhosphataseBiomarkersCase-Control StudiesChildFemaleFlow CytometryHumansLeukocytes, MononuclearMaleMiddle AgedYoung AdultAlkaline PhosphataseBiomarkersDiseases and disorders related to boneGorham-stout diseaseOsteoclast precursorsOsteoclasts

Identifiers

PMID38556572
OpenAlexW4393388674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.