Evidence map›Paper›PMID 38556255›Full record

ArticleActa psychiatrica Scandinavica2024

Alcohol use disorder and risk of specific methods of suicide death in a national cohort.

Alexis C Edwards, Linda Abrahamsson, Casey Crump, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta psychiatrica Scandinavica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Understanding suicide.Discoveries (Craiova, Romania)
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Alexis C EdwardsDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-4006-9710
Linda AbrahamssonCenter for Primary Health Care Research, Lund University, Malmö, Sweden.
Casey CrumpDepartment of Family and Community Medicine and Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, Houston, Texas, USA.
Jan SundquistCenter for Primary Health Care Research, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0001-7228-5015
Kristina SundquistCenter for Primary Health Care Research, Lund University, Malmö, Sweden.
Kenneth S KendlerDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Lund University · SEVirginia Commonwealth University · USThe University of Texas Health Science Center at Houston · US

Funding

The Etiology of Risk: Alcohol Use Disorder and Suicidal BehaviorR01AA027522 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Alexis C Edwards, Kristina Sundquist · 2019 to 2026
$3.5M
NIAAA NIH HHS R01 AA027522NIH HHS AA027522
6 · The paper itself

Abstract

introductionAlcohol use disorder (AUD) is among the strongest correlates of suicide death, but it is unclear whether AUD status is differentially associated with risk of suicide by particular methods.

methodsThe authors used competing risks models to evaluate the association between AUD status and risk of suicide by poisoning, suffocation, drowning, firearm, instruments, jumping, or other means in a large Swedish cohort born 1932-1995 (total N = 6,581,827; 48.8% female). Data were derived from Swedish national registers, including the Cause of Death Register and a range of medical registers.

resultsAfter adjusting for sociodemographic factors and familial liability to suicidal behavior, AUD was positively associated with risk of suicide for each method evaluated (cumulative incidence differences: 0.006-1.040 for females, 0.046-0.680 for males), except the association with firearm suicide in females. AUD was most strongly associated with risk of suicide by poisoning. Sex differences in the effects of AUD and family liability were observed for some, but not all, methods. Furthermore, high familial liability for suicidal behavior exacerbated AUD's impact on risk for suicide by poisoning (both sexes) and suffocation and jumping (males only), while the inverse interaction was observed for firearm suicide (males only).

conclusionsAUD increases risk of suicide by all methods examined and is particularly potent with respect to risk of suicide by poisoning. Differences in risk related to sex and familial liability to suicidal behavior underscore AUD's nuanced role in suicide risk. Future research should investigate targeted means restriction effectiveness among persons with AUD.

Indexed as

AlcoholismRegistriesSuicideAdultAgedCause of DeathCohort StudiesFemaleHumansMaleMiddle AgedRisk FactorsSex FactorsSwedenalcohol use disordercompeting risks modelsgenetic liabilitysuicide method

Identifiers

PMID38556255
PMCPMC11065572
OpenAlexW4393355801

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.