Evidence map›Paper›PMID 38556028›Full record

ReviewBiochemical pharmacology2024

Emerging roles of senolytics/senomorphics in HIV-related co-morbidities.

Gagandeep Kaur, Md Sohanur Rahman, Sadiya Shaikh, Kingshuk Panda, Srinivasan Chinnapaiyan, Maria Santiago Estevez, Li Xia, Hoshang Unwalla, Irfan Rahman

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemical pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gagandeep KaurDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Md Sohanur RahmanDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Sadiya ShaikhDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Kingshuk PandaDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Srinivasan ChinnapaiyanDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Maria Santiago EstevezDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Li XiaDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Hoshang UnwallaDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Irfan RahmanDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA. Electronic address: irfan_rahman@urmc.rochester.edu.
Florida International University · USUniversity of Rochester Medical Center · US

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
TriState SenNET (Lung and Heart) Tissue Map and Atlas consortiumU54AG075931 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOREN FINKEL, Melanie Koenigshoff · 2021 to 2026
$14.0M
The role of calcium entry through the mitochondrial uniporter in regulating cardiac metabolism and physiologyR01HL142589 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINKEL, TOREN · 2019 to 2022
$2.6M
Mechanisms of Defective Mitophagy and cellular Senescence in HIV-associated COPDR01HL147715 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI IRFAN RAHMAN, HOSHANG JEHANGIR UNWALLA · 2019 to 2026
$2.6M
Aberrant Micro-managing of the Airway Epithelial Transcriptome in HIV-associated COPDR01HL167655 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI IRFAN RAHMAN, HOSHANG JEHANGIR UNWALLA · 2023 to 2026
$2.6M
Resetting the Clock in HIV associated COPDR01HL158316 · NHLBI · FLORIDA INTERNATIONAL UNIVERSITY · PI RAHMAN, IRFAN, UNWALLA, HOSHANG JEHANGIR · 2022 to 2025
$2.1M
Molecular clock dysfunction in lung cellular senescence by environmental tobacco smokeR01ES029177 · NIEHS · UNIVERSITY OF ROCHESTER · PI RAHMAN, IRFAN · 2019 to 2023
$1.7M
NHLBI NIH HHS R01 HL142589NHLBI NIH HHS R01 HL147715NHLBI NIH HHS R01 HL158316NHLBI NIH HHS R01 HL167655NIA NIH HHS U54 AG075931NIEHS NIH HHS P30 ES001247NIEHS NIH HHS R01 ES029177
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) is known to cause cellular senescence and inflammation among infected individuals. While the traditional antiretroviral therapies (ART) have allowed the once fatal infection to be managed effectively, the quality of life of HIV patients on prolonged ART use is still inferior. Most of these individuals suffer from life-threatening comorbidities like chronic obstructive pulmonary disease (COPD), pulmonary arterial hypertension (PAH), and diabetes, to name a few. Interestingly, cellular senescence is known to play a critical role in the pathophysiology of these comorbidities as well. It is therefore important to understand the role of cellular senescence in the disease progression and co-morbidity development in HIV-infected individuals. In this respect, use of senolytic/senomorphic drugs as combination therapy with ART would be beneficial for HIV patients. This review provides a critical analysis of the current literature to determine the potential and efficacy of using senolytics/senotherapeutics in managing HIV infection, latency, and associated co-morbidities in humans. The various classes of senolytics have been studied in detail to focus on their potential to combat against HIV infections and associated pathologies with advancing age.

Indexed as

ComorbidityHIV InfectionsSenotherapeuticsAnimalsAnti-HIV AgentsCellular SenescenceHumansAnti-HIV AgentsSenotherapeuticsand miRNACo-morbiditiesHIVSenescenceSenolyticsSenomorphics

Identifiers

PMID38556028
PMCPMC11410549
OpenAlexW4393321476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.