Evidence map›Paper›PMID 38555979›Full record

ArticleThe Journal of allergy and clinical immunology2024

Renal complications in patients with predominantly antibody deficiency in the United States Immune Deficiency Network (USIDNET).

Emma Materne, Baijun Zhou, Daniel DiGiacomo, Jocelyn R Farmer, Ramsay Fuleihan, Kathleen E Sullivan, Charlotte Cunningham-Rundles, Zuhair K Ballas, Daniel Suez, Sara Barmettler and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 1 country.

Emma MaterneDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass; Harvard Medical School, Boston, Mass. Electronic address: ecmaterne@mgh.harvard.edu.
Baijun ZhouDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass.
Daniel DiGiacomoHackensack Meridian Health, Jersey Shore University Medical Center, Neptune, NJ.
Jocelyn R FarmerClinical Immunodeficiency Program, Division of Allergy and Inflammation, Beth Israel Lahey Health, Burlington, Mass.
Ramsay FuleihanDivision of Pediatric Allergy, Immunology and Rheumatology, Columbia University, New York, NY.
Kathleen E SullivanDivision of Allergy and Immunology, Children's Hospital of Pennsylvania, Philadelphia, Pa.
Charlotte Cunningham-RundlesDivision of Clinical Immunology, Mt. Sinai, New York, NY.
Zuhair K BallasDivision of Internal Medicine, Immunology, University of Iowa, Iowa City, Iowa.
Daniel SuezDS Allergy Clinic, Irving, Tex.
Sara BarmettlerDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass; Harvard Medical School, Boston, Mass.
USIDNET Consortium
Harvard University · USAllergy Clinic of Tulsa · USChildren's Hospital of Philadelphia · USColumbia University · USHackensack Meridian Health · USLahey Medical Center · USMassachusetts General Hospital · USMount Sinai Hospital · USUniversity of Iowa · US

Funding

USIDNET: A resource for clinical immunologistsR24AI171055 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI KATHLEEN E SULLIVAN · 2022 to 2026
$7.0M
Underdiagnosis of primary immunodeficiency disorders: Recognize and EducateR01MD017816 · NIMHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Jocelyn R Farmer, Mei-Sing Ong · 2022 to 2026
$3.2M
Modeling Risk for Hypogammaglobulinemia, Infections, and Mortality with Chimeric Antigen Receptor (CAR) T-cell TherapyK23AI163350 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BARMETTLER, SARA · 2021 to 2025
$1.1M
NIAID NIH HHS K23 AI163350NIAID NIH HHS R24 AI171055NIMHD NIH HHS R01 MD017816
6 · The paper itself

Abstract

backgroundPrior studies have reported that renal insufficiency occurs in a small percentage of patients with predominantly antibody deficiency (PAD) and in about 2% of patients with common variable immunodeficiency.

objectiveThe goal of our study was to understand and evaluate the prevalence and type of renal complications in patients with PAD in the United States Immunodeficiency Network (USIDNET) cohort. We hypothesized that there is an association between certain renal complications and severity of immunophenotype in patients with PAD.

methodsWe performed a query of patients with PAD from the USIDNET cohort with renal complications. Patients with documented renal disease such as chronic kidney disease (CKD), nephrolithiasis, nephritis, and renal failure syndrome were included. We compared immunophenotype, flow cytometry findings, and immunoglobulin levels of patients with PAD accompanied by renal complications with those of the total USIDNET cohort of patients with PAD.

resultsWe determined that 140 of 2071 patients with PAD (6.8%) had renal complications. Of these 140 patients, 50 (35.7%) had CKD, 46 (32.9%) had nephrolithiasis, 18 (12.9 %) had nephritis, and 50 (35.7%) had other renal complications. Compared with the total USIDNET cohort of patients with PAD, patients with CKD had lower absolute lymphocyte counts, CD3

conclusionsWe determined that 6.8% of the USIDNET cohort of patients with PAD had a documented renal complication. Compared with the overall cohort of patients with PAD, those patients with nephritis and CKD had a more severe immunophenotype.

Indexed as

Immunologic Deficiency SyndromesAdolescentAdultAgedChildCohort StudiesFemaleHumansImmunophenotypingKidney DiseasesMaleMiddle AgedPrevalenceUnited StatesYoung Adultchronic kidney diseasecommon variable immunodeficiencyimmunophenotypeinborn errors of immunitynephritispredominantly antibody deficiencyPrimary immunodeficiencyrenal disease

Identifiers

PMID38555979
PMCPMC11955191
OpenAlexW4393306952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.