Evidence map›Paper›PMID 38555519›Full record

ReviewRNA biology2024

RNA nanostructures for targeted drug delivery and imaging.

Laura Teodori, Marjan Omer, Jørgen Kjems

Open access · goldAbstract readReview
In one paragraph

Review in RNA biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Synthetic RNA biology.RNA biology · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laura TeodoriInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, Denmark.ORCID 0000-0003-1294-305X
Marjan OmerInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, Denmark.ORCID 0000-0002-7557-5664
Jørgen KjemsInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C, Denmark.ORCID 0000-0003-4128-9317
Aarhus University · DK

Funding

Danish National Research Foundation (Centre for Cellular Signal Patterns DNRF135Novo Nordisk Foundation NNF23OC0081177, RNA-METANovo Nordisk Foundation NNF23OC0082848
6 · The paper itself

Abstract

The RNA molecule plays a pivotal role in many biological processes by relaying genetic information, regulating gene expression, and serving as molecular machines and catalyzers. This inherent versatility of RNA has fueled significant advancements in the field of RNA nanotechnology, driving the engineering of complex nanoscale architectures toward biomedical applications, including targeted drug delivery and bioimaging. RNA polymers, serving as building blocks, offer programmability and predictability of Watson-Crick base pairing, as well as non-canonical base pairing, for the construction of nanostructures with high precision and stoichiometry. Leveraging the ease of chemical modifications to protect the RNA from degradation, researchers have developed highly functional and biocompatible RNA architectures and integrated them into preclinical studies for the delivery of payloads and imaging agents. This review offers an educational introduction to the use of RNA as a biopolymer in the design of multifunctional nanostructures applied to targeted delivery

Indexed as

NanostructuresNeoplasmsDNAHumansNanotechnologyRNADNARNAaptamersbioconjugationbioimagingcancerpersonalized nanomedicineRNA nanostructuresRNA therapeuticstargeted drug deliverytumour targeting

Identifiers

PMID38555519
PMCPMC10984137
OpenAlexW4393356084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.