ArticleScientific reports2024
The bidirectional associations between sarcopenia-related traits and cognitive performance.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- A Systematic Review and Meta-analysis on the association between sarcopenia and cognitive impairment in middle-aged and older adults from Latin America.The journal of nutrition, health & aging · 2026Pooled it
- Cognitive Impairment and Long-Term Cognitive Trajectories in Relation to Incident Sarcopenia.Annals of geriatric medicine and research · 2026Article
- Handgrip strength and relationship with non-motor symptoms in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Sarcopenia Severity and the Accumulation of Geriatric Syndromes Among Older Adults: A Cross-Sectional Study from Vietnam.Geriatrics (Basel, Switzerland) · 2026Article
- The association between sarcopenia, sedentary behavior, and the motor cognitive risk syndrome: A Mendelian randomization study.Medicine · 2026Article
- A practical estimation equation for appendicular skeletal muscle mass in stroke rehabilitation: validating diagnostic accuracy and predicting functional outcomes.European geriatric medicine · 2026Article
- Early Microstructural Changes in the Left Inferior Fronto-Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed.Brain and behavior · 2026Article
- Integrative physiology of skeletal muscle for maintaining cognitive health.The Journal of physiology · 2026Review
- Associations of Sarcopenia and Sarcopenic Obesity Using Different Obesity Definitions With Memory Decline.Journal of diabetes · 2026Article
- The weight-adjusted waist index predicts sarcopenia in community-dwelling older adults in a nationwide multicenter prospective study.Scientific reports · 2026Article
- Effect of Hand Grip Strength on Perioperative Outcomes in Older Female Patients Scheduled for Total Knee Arthroplasty Under General Anesthesia-A Prospective Observational Study.Journal of clinical medicine · 2026Article
- The mediating effect of arteriosclerosis on the relationship between sarcopenia and cognitive impairment: a retrospective analysis.Frontiers in medicine · 2026Article
- Nutritional intervention targeting muscle-brain axis in dementia continuum: from mechanisms to practice.Frontiers in nutrition · 2026Review
- Article
- Preserved muscle function as a protective factor against cognitive decline: Longitudinal results from the FINGER study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Sarcopenia and its Cognitive Consequences: Insights from an Urban Indian Cohort.Annals of Indian Academy of Neurology · 2025Article
- Genetic Influence of the Brain on Muscle Structure: A Mendelian Randomization Study of Sarcopenia.Journal of cachexia, sarcopenia and muscle · 2025Article
- Body composition and cognitive function in Chinese rural adults: an exploratory factor analysis and network analysis.Frontiers in aging neuroscience · 2025Article
- Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.American journal of translational research · 2025Article
- Interaction and overall effects of underweight, low muscle mass, malnutrition, and inflammation on early-onset mild cognitive impairment in type 2 diabetes.Frontiers in aging neuroscience · 2025Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
While many studies have sought to explore the degree to which sarcopenia-related traits are associated with cognitive performance, these studies have yielded contradictory results without any clear indication of the causality of such relationships. In efforts to better understand associations between sarcopenia-related traits and cognitive ability, a series of multivariate linear regression assessments were carried out upon datasets derived through the National Health and Nutrition Examination Survey (NHANES). Of these, cognitive performance was assessed by the Digit Symbol Substitution Test (DDST), the Consortium to Establish a Registry for Alzheimer's Disease Immediate Recall Test (CERAD-IR), Delayed Recall Test (CERAD-DR) and Animal Fluency Test (AFT). Causal relationships between the two were further inferred via a two-sample Mendelian randomization (MR) analysis approach. Sarcopenia-related traits considered in these assessments included walking speed, appendicular skeletal muscle mass (ASM), and hand grip strength (HGS). Walking speed, ASM, and HGS were all significantly independently related to cognitive scores following adjustment for covariates. MR assessments also identified that each 1-SD higher walking speed and appendicular lean mass were causally and respectively associated with a 0.34 [standard error (SE) = 0.09; p < 0.001)] standardized score higher and a 0.07 (SE = 0.01; p < 0.001) standardized score higher cognitive score, whereas a higher hand grip strength was positively associated with a better cognitive performance. Reverse MR assessments also yielded similar findings. These data suggest that lower walking speed, muscle strength, and muscle mass were all closely related to lower cognitive performance irrespective of gender, and that there may be a mutually reinforcing relationship among these variables.
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