ArticleScientific reports2024
Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 26 citations in OpenAlex.
- Benzo[ACS omega · 2026Article
- Design, Synthesis, Antimicrobial and Antitumor Activities of Benzo[f]chromene Derivatives: DFT and Molecular Docking.Anti-cancer agents in medicinal chemistry · 2026Article
- Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis,Future medicinal chemistry · 2025Article
- Synthesis of Schiff bases based on Chitosan, thermal stability and evaluation of antimicrobial and antitumor activities.Scientific reports · 2025Article
- From Bench to Bioactivity: Pyranopyrazole Synthesis, Anticancer, Antimicrobial Efficacy, DFT, Molecular Docking, and Molecular Dynamic Insights.Anti-cancer agents in medicinal chemistry · 2025Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
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Abstract
P-glycoprotein (P-gp) imparts multi-drug resistance (MDR) on the cancers cell and malignant tumor clinical therapeutics. We report a class of newly designed and synthesized oxygen-heterocyclic-based pyran analogues (4a-l) bearing different aryl/hetaryl-substituted at the 1-postion were synthesized, aiming to impede the P-gp function. These compounds (4a-l) have been tested against cancerous PC-3, SKOV-3, HeLa, and MCF-7/ADR cell lines as well as non-cancerous HFL-1 and WI-38 cell lines to determine their anti-proliferative potency.The findings demonstrated the superior potency of 4a-c with 4-F, 2-Cl, and 3-Cl derivatives and 4h,g with 4-NO
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