ArticleAnnals of intensive care2024
The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years.
Article in Annals of intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03370692 (Development and Validation of a Prognostic Score in the Very Old ICU Patients), which is not on this map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development and Validation of a Prognostic Score in the Very Old ICU Patients (≥80 Years)
Who cites it
16 citing papers in PubMed.
- Sublingual microcirculatory assessment on admission independently predicts the outcome of old intensive care patients suffering from shock.Scientific reports · 2024Trial
- Comparison of the Hospital Burden Associated with Respiratory Syncytial Virus and Human Metapneumovirus Across All Age Groups in Scotland: A Retrospective Analysis.Infectious diseases and therapy · 2026Article
- Hospitalisation Burden of Human Metapneumovirus and Respiratory Syncytial Virus in Adults by Age and Comorbidity Status in Scotland: A Retrospective Analysis.Infectious diseases and therapy · 2026Article
- Creation of a dedicated post-intensive care geriatric unit (PIGU), proof of concept and preliminary results.European geriatric medicine · 2026Article
- Critical care of the very old, what needs to be done?European geriatric medicine · 2026Review
- One-Year Outcomes After ICU Discharge in Patients Aged 80 Years and Older: Functional and Clinical Factors Associated with Mortality in a Retrospective Observational Cohort.Journal of clinical medicine · 2026Article
- Observational
- Enhancing large language model clinical support information with machine learning risk and explainability: a feasibility study.Intensive care medicine experimental · 2026Article
- Human Metapneumovirus-associated Hospital Burden in Older Adults in Scotland: A Retrospective Analysis.Open forum infectious diseases · 2026Article
- Article
- Long-term frailty trajectory in older ICU survivors requiring mechanical ventilation: a prospective cohort study in Norway.Annals of intensive care · 2026Article
- Characteristics and outcomes of diabetes emergencies in nonagenarians admitted to ICU: a binational retrospective cohort study.Frontiers in clinical diabetes and healthcare · 2026Article
- Characteristics, outcomes, and complications among nonagenarian and centenarian patients admitted to the intensive care unit: a scoping review.Critical care (London, England) · 2025Article
- Prolonged intensive care therapy in nonagenarians admitted to the intensive care unit-clinical characteristics, risk factors and outcomes.Frontiers in medicine · 2025Article
- The long-term conditional mortality rate in older ICU patients compared to the general population.Critical care (London, England) · 2024Article
- Frailty is crucial in FORECASTing outcomes in critical care.Intensive care medicine · 2024Article
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Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPremorbid conditions influence the outcome of acutely ill adult patients aged 80 years and over who are admitted to the ICU. The aim of this study was to determine the influence of such premorbid conditions on 6 month survival.
methodsProspective cohort study in 242 ICUs from 22 countries including patients 80 years or above, admitted over a 6 months period to an ICU between May 2018 and May 2019. Only emergency (acute) ICU admissions in adult patients ≥ 80 years of age were eligible. Patients who were admitted after planned/elective surgery were excluded. We measured the Clinical Frailty Scale (CFS), the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), disability with the Katz activities of daily living (ADL) score, comorbidities and a Polypharmacy Score (CPS).
resultsOverall, the VIP2 study included 3920 patients. During ICU stay 1191 patients died (30.9%), and another 436 patients (11.1%) died after ICU discharge but within the first 30 days of admission, and an additional 895 patients died hereafter but within the first 6 months after admission (22.8%). The 6 months mortality was 64%. The median CFS was 4 (IQR 3-6). Frailty (CFS ≥ 5) was present in 26.6%. Cognitive decline (IQCODE above 3.5) was found in 30.2%. The median IQCODE was 3.19. A Katz ADL of 4 or less was present in 27.7%. Patients who surviving > 6 months were slightly younger (median age survivors 84 with IQR 81-86) than patients dying within the first 6 months (median age 84, IQR 82-87, p = 0.013), were less frequently frail (CFS > 5 in 19% versus 34%, p < 0.01) and were less dependent based on their Katz activities of daily living measurement (median Katz score 6, IQR 5-6 versus 6 points, IQR 3-6, p < 0.01).
conclusionsWe found that Clinical Frailty Scale, age, and SOFA at admission were independent prognostic factors for 6 month mortality after ICU admission in patients age 80 and above. Adding other geriatric syndromes and scores did not improve the model. This information can be used in shared-decision making. CLINICALTRIALS: gov: NCT03370692.
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