Evidence map›Paper›PMID 38555277›Full record

ArticleScientific reports2024

Unraveling the complex interplay between obesity and vitamin D metabolism.

Bashar Alzohily, Asma AlMenhali, Salah Gariballa, Nayla Munawar, Javed Yasin, Iltaf Shah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
20.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  14. Intersecting and intricacy pathways of Vitamin D and Fluoride in obesity.Journal of family medicine and primary care · 2025
    Article
  15. Article
  16. Article
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  20. The Association ofDiseases (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bashar AlzohilyDepartment of Chemistry, College of Science, UAE University, 15551, Al Ain, UAE.
Asma AlMenhaliDepartment of Biology, College of Science, UAE University, 15551, Al Ain, UAE.
Salah GariballaInternal Medicine, Faculty of Medicine and Health Sciences, UAE University, 15551, Al Ain, UAE.
Nayla MunawarDepartment of Chemistry, College of Science, UAE University, 15551, Al Ain, UAE.
Javed YasinInternal Medicine, Faculty of Medicine and Health Sciences, UAE University, 15551, Al Ain, UAE.
Iltaf ShahDepartment of Chemistry, College of Science, UAE University, 15551, Al Ain, UAE. altafshah@uaeu.ac.ae.
United Arab Emirates University · AE

Funding

United Arab Emirates University 12S091United Arab Emirates University 31R138United Arab Emirates University G00003117
6 · The paper itself

Abstract

Vitamin D deficiency and obesity are a worldwide health issue. Obesity refers to the accumulation of excessive fats in the body which could lead to the development of diseases. Obese people have low vitamin D levels for several reasons including larger volume of distribution, vitamin D tightly bound in fatty tissues, reduced absorption, and diets with low vitamin D. Accurately measuring vitamin D metabolites is challenging. The Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS) method was developed and validated for the analysis of vitamin D metabolites in the serum. Blood samples were collected from 452 subjects which consisted of baseline (vitamin D deficient obese subjects), follow-up (supplemented obese subjects), and healthy volunteers. The vitamin D metabolites were separated adequately by the developed UHPLC-MS/MS method. Moreover, the validation criteria for the method were within an acceptable range. The baseline, follow-up and even healthy volunteers were deficient in 25OHD3 and 25OHD2. The baseline and healthy subjects had comparable concentration of vitamin D2 and D3. However, healthy subjects had a higher concentration of 25OHD and its epimer compared to the baseline subjects. The vitamin D3 was increased significantly in the follow- up subjects; therefore, the 25OHD3 was increased significantly compared to the baseline as well; however, the increase was insufficient to achieve the optimal range. The UHPLC-MS/MS method test was applied successfully on estimation of vitamin D metabolites in subjects. This study indicates the significance of taking into account the metabolic and storage effects when evaluating the vitamin D status in obese subjects.

Indexed as

Tandem Mass SpectrometryVitamin DChromatography, LiquidErgocalciferolsHumansObesityVitaminsErgocalciferolsVitamin DVitaminsEpimers of vitamin DObese subjects vitamin D deficiencyUHPLC-MS/MSVitamin DVitamin D blood measurement testVitamin D metabolites

Identifiers

PMID38555277
PMCPMC10981658
OpenAlexW4393336917

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.