Evidence map›Paper›PMID 38555153›Full record

ArticleMethods in cell biology2024

In vitro osteoclastogenesis assessment using murine myeloid-derived suppressor cells.

Kyu Hwan Kwack, Lixia Zhang, Keith L Kirkwood

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Innate Immunity and Synovitis: Key Players in Osteoarthritis Progression.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Kyu Hwan KwackDepartment of Oral Biology, University at Buffalo, Buffalo, NY, United States; Department of Oral Microbiology, College of Dentistry, Kyung Hee University, Seoul, Republic of Korea. Electronic address: dmdkwack@khu.ac.kr.
Lixia ZhangDepartment of Oral Biology, University at Buffalo, Buffalo, NY, United States.
Keith L KirkwoodDepartment of Oral Biology, University at Buffalo, Buffalo, NY, United States; Department of Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
University at Buffalo, State University of New York · US

Funding

Immunometabolic Regulation of MDSCs in PeriodontitisR01DE032310 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Keith L Kirkwood · 2022 to 2026
$2.9M
Post-Transcriptional Control of Aging-Associated Inflammation and Bone Homeostasis (Administrative Supplement)R01DE028258 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI KIRKWOOD, KEITH L · 2018 to 2022
$2.1M
NIDCR NIH HHS R01 DE028258NIDCR NIH HHS R01 DE032310
6 · The paper itself

Abstract

The study of myeloid-derived suppressor cells (MDSCs) has been commonly reported in the context of cancer immunology. MDSCs play a key role in cancer growth and progression by inhibiting both innate and adaptive immunity. In addition to the immunosuppressive function of MDSCs in cancer, a novel function of MDSCs as osteoclast precursors has recently been attracting attention. Because monocytic-MDSCs (M-MDSCs) are derived from the same myeloid lineage as macrophages, which are osteoclast progenitors, M-MDSCs can undergo differentiation into osteoclasts, contributing to bone destruction not only in the cancer microenvironment but also in inflammatory conditions including obesity and osteoarthritis. Herein, we present details of the technique to evaluate osteoclasts in vitro, as well as specific techniques to isolate M-MDSCs and identify them. This protocol can be easily adapted to isolate M-MDSCs from most pathologic conditions for easy evaluation.

Indexed as

Myeloid-Derived Suppressor CellsNeoplasmsAnimalsMiceOsteogenesisTumor MicroenvironmentMonocytic myeloid-derived suppressor cellsMyeloid-derived suppressor cellsOsteoclastOsteoclastogenesis

Identifiers

PMID38555153
PMCPMC11287231
OpenAlexW4387645204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.