Evidence map›Paper›PMID 38555105›Full record

ArticleJournal of clinical pathology2025

Morphology combined with

Caroline M Joyce, Geoffrey J Maher, Susan Dineen, Nirosha Suraweera, Tommie V McCarthy, John Coulter, Keelin O'Donoghue, Michael J Seckl, Brendan Fitzgerald

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Insights into Reproductive Immunology and Placental Pathology, 2nd Edition.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Caroline M JoycePregnancy Loss Research Group, Department of Obstetrics & Gynaecology, University College Cork, Cork, Ireland carolinejoyce@ucc.ie.ORCID http://orcid.org/0000-0001-7231-8331
Geoffrey J MaherTrophoblastic Tumour Screening & Treatment Centre, Imperial College NHS Trust, Charing Cross Hospital, London, UK.ORCID http://orcid.org/0000-0001-7135-4824
Susan DineenPregnancy Loss Research Group, Department of Obstetrics & Gynaecology, University College Cork, Cork, Ireland.
Nirosha SuraweeraTrophoblastic Tumour Screening & Treatment Centre, Imperial College NHS Trust, Charing Cross Hospital, London, UK.
Tommie V McCarthyDepartment of Biochemistry & Cell Biology, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0003-4884-6972
John CoulterDepartment of Obstetrics & Gynaecology, Cork University Maternity Hospital, Cork, Ireland.
Keelin O'DonoghuePregnancy Loss Research Group, Department of Obstetrics & Gynaecology, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0002-4616-2887
Michael J SecklTrophoblastic Tumour Screening & Treatment Centre, Imperial College NHS Trust, Charing Cross Hospital, London, UK.
Brendan FitzgeraldPregnancy Loss Research Group, Department of Obstetrics & Gynaecology, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0002-8509-088X
University College Cork · IECharing Cross Hospital · GBCork University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsA hydatidiform mole (HM) is classified as complete (CHM) or partial (PHM) based on its morphology and genomic composition. Ancillary techniques are often required to confirm a morphologically suspected PHM diagnosis. This study sought to evaluate the clinical accuracy of PHM diagnosis using morphological assessment supported by

methodsOver a 2-year period, our unit examined 1265 products of conception (POCs) from which 103 atypical POCs were diagnosed as PHM or non-molar conceptuses with the assistance of

resultsThirty-six of the 40 cases (19 PHM and 17 non-molar) were successfully genotyped and demonstrated complete concordance with the original diagnosis. All PHMs were diandric triploid of dispermic origin. In two non-molar diploid cases, we identified suspected trisomies (13 and 18), which potentially explains the pregnancy loss in these cases.

conclusionsThis study validates the use of

Indexed as

Erb-b2 Receptor Tyrosine KinasesGenotyping TechniquesHydatidiform MoleIn Situ HybridizationPloidiesUterine NeoplasmsAdultFemaleGenotypeHumansMicrosatellite RepeatsPredictive Value of TestsPregnancyRetrospective StudiesERBB2 protein, humanErb-b2 Receptor Tyrosine Kinasesgeneticsimmunohistochemistrymoles

Identifiers

PMID38555105
PMCPMC12015085
OpenAlexW4393336922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.