Evidence map›Paper›PMID 38554281›Full record

ArticleCell reports2024

Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration.

Georgia Dermentzaki, Mattia Furlan, Iris Tanaka, Tommaso Leonardi, Paola Rinchetti, Patricia M S Passos, Alliny Bastos, Yuna M Ayala, Jacob H Hanna, Serge Przedborski and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. The role of mNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  2. Article
  3. Review
  4. The mCells · 2025
    Review
  5. Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  6. Epitranscriptomic alterations induced by environmental toxins: implications for RNA modifications and disease.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
  7. METTL3-mediated mActa biochimica et biophysica Sinica · 2025
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Georgia DermentzakiCenter for Motor Neuron Biology and Disease, Departments of Pathology & Cell Biology and Neurology, Columbia University, New York, NY, USA.
Mattia FurlanCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Milan, Italy.
Iris TanakaCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Milan, Italy.
Tommaso LeonardiCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Milan, Italy.
Paola RinchettiCenter for Motor Neuron Biology and Disease, Departments of Pathology & Cell Biology and Neurology, Columbia University, New York, NY, USA.
Patricia M S PassosDepartment of Biochemistry & Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri, USA.
Alliny BastosDepartment of Biochemistry & Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri, USA.
Yuna M AyalaDepartment of Biochemistry & Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri, USA.
Jacob H HannaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Serge PrzedborskiCenter for Motor Neuron Biology and Disease, Departments of Pathology & Cell Biology and Neurology, Columbia University, New York, NY, USA; Department of Neuroscience, Columbia University, New York, NY, USA.
Dario BonanomiDivision of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Mattia PelizzolaCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Milan, Italy; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
Francesco LottiCenter for Motor Neuron Biology and Disease, Departments of Pathology & Cell Biology and Neurology, Columbia University, New York, NY, USA. Electronic address: fl2219@cumc.columbia.edu.
Italian Institute of Technology · ITSaint Louis University · USColumbia University · USColumbia University Irving Medical Center · USVita-Salute San Raffaele University · ITWeizmann Institute of Science · IL

Funding

METTL3-mediated regulation of motor neuron functionR01AG084965 · NIA · HUNTER COLLEGE · PI Francesco Lotti · 2023 to 2026
$1.1M
NIA NIH HHS R01 AG084965
6 · The paper itself

Abstract

Motor neuron (MN) demise is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Post-transcriptional gene regulation can control RNA's fate, and defects in RNA processing are critical determinants of MN degeneration. N

Indexed as

Cholinergic NeuronsMethyltransferasesNeuromuscular DiseasesAdenosineAmyotrophic Lateral SclerosisAnimalsDNA-Binding ProteinsHumansMiceMotor NeuronsAdenosineDNA-Binding ProteinsMethyltransferasesMETTL3 protein, humanMettl3 protein, mouseN-methyladenosineage-related neurodegenerationALSamyotrophic lateral sclerosisCP: Neurosciencefrontotemporal dementiaFTDm6Amethyltransferase-like 3METTL3motor neuronsN6-methyladenosineRNA epigeneticsRNA metabolismTDP-43transactive response DNA-binding protein-43

Identifiers

PMID38554281
PMCPMC11216409
OpenAlexW4393349259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.