Evidence map›Paper›PMID 38554257›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024

The Association Between Postural Sway and Preclinical Alzheimer Disease Among Community-Dwelling Older Adults.

Rebecca M Bollinger, Szu-Wei Chen, Melissa J Krauss, Audrey A Keleman, Abigail Kehrer-Dunlap, Megan Kaesler, Beau M Ances, Susan L Stark

Abstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Falls predict faster progression to Alzheimer's dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Review
  3. Review
  4. Integrating Machine Learning and Environmental and Genetic Risk Factors for the Early Detection of Preclinical Alzheimer's Disease.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  5. Longitudinal investigation of gait and Alzheimer's disease in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecca M BollingerProgram in Occupational Therapy, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-1931-8372
Szu-Wei ChenProgram in Occupational Therapy, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Melissa J KraussProgram in Occupational Therapy, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-8726-7394
Audrey A KelemanProgram in Occupational Therapy, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0003-1025-3100
Abigail Kehrer-DunlapProgram in Occupational Therapy, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0001-6569-0960
Megan KaeslerProgram in Occupational Therapy, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Beau M AncesDepartment of Neurology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Susan L StarkProgram in Occupational Therapy, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.ORCID 0000-0002-2816-7158

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
FALLS: A MARKER OF PRECLINICAL ALZHEIMERS DISEASER01AG057680 · NIA · WASHINGTON UNIVERSITY · PI ANCES, BEAU M, STARK, SUSAN LYNN · 2018 to 2022
$3.4M
Daniel J. Brennan MD FundHealthy Aging and Senile Dementia Program Project P01 AG03991NIA NIH HHS 1 R01 AG057680-01A1NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG057680NIH HHS 1 R01 AG057680-01A1Paula C. and Rodger O. Riney Fund
6 · The paper itself

Abstract

backgroundIt is unknown whether older adults with preclinical Alzheimer disease (AD) experience changes in postural sway compared with those without preclinical AD. The purpose of this study was to understand the effect of dual tasking on standing balance, or postural sway, for people with and without preclinical AD.

methodsA cross-sectional analysis of baseline data from a longitudinal cohort study. Participants were cognitively normal older adults with and without preclinical AD. Postural sway (path length) was tested using a force plate under standard and dual task balance conditions. Dual task cost (DTC) was calculated to examine performance change in balance conditions. Logistic regression models were used to predict preclinical AD status as a function of DTC.

results203 participants (65 preclinical AD+) were included. DTC for path length was significantly greater for participants with preclinical AD (DTC path length mean difference 19.8, 95% CI 2.6-37.0, t(201) = 2.29, p = .024). Greater DTC was significantly associated with increased odds of having preclinical AD (adjusted odds ratio for a 20-unit increase in DTC 1.16, 95% CI 1.02-1.32).

conclusionsOlder adults with preclinical AD are more likely to demonstrate significantly greater DTC in postural sway than those without preclinical AD. Dual tasking should be integrated into balance and fall risk assessments and may inform early detection of preclinical AD.

Indexed as

Alzheimer DiseaseIndependent LivingPostural BalanceAgedAged, 80 and overCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleBalanceDual taskFallsPhysical performancePreclinical Alzheimer disease

Identifiers

PMID38554257
PMCPMC11167487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.