Evidence map›Paper›PMID 38554125›Full record

ArticleEuropean heart journal2024

A streamlined pathway for transcatheter aortic valve implantation: the BENCHMARK study.

Derk Frank, Eric Durand, Sandra Lauck, Douglas F Muir, Mark Spence, Mariuca Vasa-Nicotera, David Wood, Francesco Saia, Cristóbal A Urbano-Carrillo, Damien Bouchayer and 34 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04579445 (Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing Transcatheter Aortic Valve Implantation in Europe - The BENCHMARK Registry), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04579445 completednot on this map

Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing Transcatheter Aortic Valve Implantation in Europe - The BENCHMARK Registry

Typeobservational_patient_registrySponsorInstitut für Pharmakologie und Präventive MedizinRan2021 to 2024Enrolled2,408ConditionsTranscatheter Aortic Valve Implantation (TAVI)ArmsEducation on tailored Quality Improvement measures
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Same-Day Discharge After Transcatheter Aortic Valve Implantation: Who, When, and How?Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Review
  7. The implementation of a streamlined TAVI patient pathway across five European countries: BENCHMARK registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Observational
  8. Article
  9. Timely hospital discharge in TAVI patients: towards a patient-centered care pathway.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Review
  10. Article
  11. Article
  12. Local anesthesia alone versus with sedation for transcatheter aortic valve implantation: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  13. Article
  14. Article
  15. A Streamline Strategy for Indication and Length of Telemetry Monitoring After TAVR.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Observational
  16. Article
  17. Transcatheter aortic valve implantation: latest evidence, gaps in knowledge, and future directions.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025
    Review
  18. Article
  19. Development and validation of the D-PACE scoring system to predict delayed high-grade conduction disturbances after transcatheter aortic valve implantation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Derk FrankDepartment of Internal Medicine III (Cardiology, Angiology and Intensive Care Medicine), University Clinical Centre Schleswig-Holstein (UKSH), Arnold-Heller Strasse 3, Haus K3, Kiel 24105, Germany.ORCID 0000-0001-7561-075X
Eric DurandDepartment of Cardiology, Univ Rouen Normandie, Inserm U1096, CHU Rouen, Rouen, France.ORCID 0000-0001-8171-7959
Sandra LauckCentre for Cardiovascular Innovation, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-0181-559X
Douglas F MuirCardiology Department, James Cook University Hospital, Middlesbrough, UK.ORCID 0000-0003-1871-2869
Mark SpenceCardiology Department, Mater Private Network, Dublin, Ireland.
Mariuca Vasa-NicoteraCardiology Department, Hospital Sindelfingen-Böblingen, Sindelfingen, Germany.
David WoodCentre for Cardiovascular Innovation, University of British Columbia, Vancouver, BC, Canada.
Francesco SaiaDepartment of Cardiology, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.ORCID 0000-0001-9969-2649
Cristóbal A Urbano-CarrilloCardiology Department, Hospital Regional Universitario de Málaga, Malaga, Spain.ORCID 0000-0002-9504-8861
Damien BouchayerDepartment of Cardiology, The Clinique de l'Infirmerie Protestante, Lyon, France.
Vlad Anton IliescuDepartment of Cardiology, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.ORCID 0000-0002-7290-3300
Christophe Saint EtienneDepartment of Cardiology, Centre Hospitalier Régional Universitaire (CHRU) de Tours, Hôpital Trousseau, Tours, France.
Florence LeclercqCardiology Department, Montpellier University Hospital, Montpellier University, Montpellier, France.ORCID 0000-0001-5936-5184
Vincent AuffretUniversité de Rennes 1, CHU Rennes Service de Cardiologie, Inserm LTSI U1099, Rennes, France.ORCID 0000-0002-9481-646X
Lluis AsmaratsServicio de Cardiología, Hospital de la Santa Creu i Sant Pau, Instituto de Investigación Biomédica Sant Pau, Barcelona, Spain.ORCID 0000-0002-3357-5834
Carlo Di MarioStructural Interventional Cardiology Division, Department of Clinical & Experimental Medicine, Careggi University Hospital, Florence, Italy.ORCID 0000-0002-4461-2055
Aurelie VeugeoisDepartment of Cardiology, Institut Mutualiste Montsouris, Paris, France.
Jiri MalyCardiac Center, IKEM Prague, Prague, Czech Republic.ORCID 0000-0002-7863-245X
Andreas SchoberDepartment of Cardiology, Hospital Floridsdorf, Vienna, Austria.ORCID 0000-0003-1410-6108
Luis Nombela-FrancoInstituto Cardiovascular, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.ORCID 0000-0003-3438-8907
Nikos WernerMedical Department III, Heart Center Trier, Krankenhaus der Barmherzigen Brüder, Trier, Germany.
Joan Antoni Gómez-HospitalHeart Diseases Institute, Bellvitge University Hospital-IDIBELL, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-3249-3095
Julia MascherbauerDepartment of Internal Medicine 3/Cardiology, University Hospital St. Pölten, St. Pölten, Austria.ORCID 0000-0001-7478-1450
Giuseppe MusumeciStruttura Complessa of Cardiology, Ospedale Mauriziano, Torino, Italy.ORCID 0000-0001-6016-5702
Nicolas MeneveauCardiology, Besancon Regional University Hospital Center, Besancon, France.ORCID 0000-0002-1017-0463
Thibaud MeuriceCardiology, Polyclinique Du Bois, Lille, France.
Felix MahfoudInternal Medicine III, Cardiology, Angiology and Internal Intensive Care Medicine, University Hospital of Saarland, Homburg, Germany.ORCID 0000-0002-4425-549X
Federico De MarcoCardiology, Centro Cardiologico Monzino, Milan, Italy.ORCID 0000-0003-3554-6938
Tim SeidlerDepartment of Cardiology and Pulmonology, Georg-August-University, Göttingen, Germany.ORCID 0000-0002-6158-5087
Florian LeuschnerDepartment of Medicine III, University of Heidelberg, German Centre for Cardiovascular Research (DZHK), Heilderberg, Germany.ORCID 0000-0003-1157-474X
Patrick JolyDepartment of Interventional Cardiology, Hôpital Saint Joseph, Marseille, France.
Jean-Philippe ColletDepartment de Cardiologie, Hôpital de Pitié-Salpêtrière AP-HP, Paris, France.ORCID 0000-0003-3750-5347
Ferdinand VogtDepartment for Cardiovascular Surgery, Artemed Klinikum München, München, Germany.ORCID 0000-0002-1924-6823
Emilio Di LorenzoDivision of Cardiology, Department of Cardiovascular Surgery, L'Ospedale S.Giuseppe Moscati di Avellino, Avellino, Italy.
Elmar KuhnDepartment of Cardiothoracic Surgery, Heart Center, Faculty of Medicine, University Hospital of Cologne, Cologne, Germany.ORCID 0000-0001-6301-7422
Vicente Peral DisdierCardiology Department, University Hospital Son Espases, Palma de Mallorca, Spain.ORCID 0000-0003-0379-5243
Violetta HachaturyanInstitute for Pharmacology and Preventive Medicine, Cloppenburg, Germany.ORCID 0000-0002-0279-3476
Claudia M LüskeInstitute for Pharmacology and Preventive Medicine, Cloppenburg, Germany.ORCID 0000-0001-7084-0628
Radka RakovaEdwards Lifesciences, Prague, Czech Republic.ORCID 0009-0000-5151-7542
Wilbert WesselinkEdwards Lifesciences, Prague, Czech Republic.ORCID 0000-0001-6494-2919
Jana KurucovaEdwards Lifesciences, Prague, Czech Republic.ORCID 0009-0003-4704-0499
Peter BramlageInstitute for Pharmacology and Preventive Medicine, Cloppenburg, Germany.ORCID 0000-0003-4970-2110
Gemma McCalmontCardiology Department, James Cook University Hospital, Middlesbrough, UK.ORCID 0000-0001-6322-072X
BENCHMARK Investigator Group

Funding

Edwards Lifesciences and performed under the sponsorship of IPPMedInstitute for Pharmacology and Preventive Medicine GmbH
6 · The paper itself

Abstract

BACKGROUND AND

aimsThere is significant potential to streamline the clinical pathway for patients undergoing transcatheter aortic valve implantation (TAVI). The purpose of this study was to evaluate the effect of implementing BENCHMARK best practices on the efficiency and safety of TAVI in 28 sites in 7 European countries.

methodsThis was a study of patients with severe symptomatic aortic stenosis (AS) undergoing TAVI with balloon-expandable valves before and after implementation of BENCHMARK best practices. Principal objectives were to reduce hospital length of stay (LoS) and duration of intensive care stay. Secondary objective was to document patient safety.

resultsBetween January 2020 and March 2023, 897 patients were documented prior to and 1491 patients after the implementation of BENCHMARK practices. Patient characteristics were consistent with a known older TAVI population and only minor differences. Mean LoS was reduced from 7.7 ± 7.0 to 5.8 ± 5.6 days (median 6 vs. 4 days; P < .001). Duration of intensive care was reduced from 1.8 to 1.3 days (median 1.1 vs. 0.9 days; P < .001). Adoption of peri-procedure best practices led to increased use of local anaesthesia (96.1% vs. 84.3%; P < .001) and decreased procedure (median 47 vs. 60 min; P < .001) and intervention times (85 vs. 95 min; P < .001). Thirty-day patient safety did not appear to be compromised with no differences in all-cause mortality (0.6% in both groups combined), stroke/transient ischaemic attack (1.4%), life-threatening bleeding (1.3%), stage 2/3 acute kidney injury (0.7%), and valve-related readmission (1.2%).

conclusionsBroad implementation of BENCHMARK practices contributes to improving efficiency of TAVI pathway reducing LoS and costs without compromising patient safety.

Indexed as

Aortic Valve StenosisBenchmarkingLength of StayTranscatheter Aortic Valve ReplacementAgedAged, 80 and overCritical PathwaysEuropeFemaleHumansMalePatient SafetyPostoperative ComplicationsAortic stenosisClinical careHealth servicesProspective registryQuality of careTAVITranscatheter aortic valve implantation

Identifiers

PMID38554125
PMCPMC11143387

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Registered trials

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