Evidence map›Paper›PMID 38553892›Full record

ReviewPediatric blood & cancer2024

Rhabdoid tumor predisposition syndrome: A historical review of treatments and outcomes for associated pediatric malignancies.

Sarah Andres, Karen Huang, Margaret Shatara, Mohamed S Abdelbaki, Mark Ranalli, Jonathan Finlay, Ajay Gupta

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatric blood & cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Small-Molecule Drugs in Pediatric Neuro-Oncology.Current oncology (Toronto, Ont.) · 2025
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Sarah AndresJacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, New York, USA.
Karen HuangJacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, New York, USA.
Margaret ShataraThe Division of Hematology and Oncology, St. Louis Children's Hospital, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Mohamed S AbdelbakiThe Division of Hematology and Oncology, St. Louis Children's Hospital, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID https://orcid.org/0000-0002-8262-7469
Mark RanalliDivision of Hematology/Oncology/Bone Marrow Transplant, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA.
Jonathan FinlayDepartments of Pediatrics and Radiation Oncology, The Ohio State University College of Medicine, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-8312-6586
Ajay GuptaDivision of Pediatric Oncology, Department of Pediatrics, Roswell Park Comprehensive Cancer Center, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.ORCID https://orcid.org/0000-0001-6074-9847
St. Louis Children's Hospital · USUniversity at Buffalo, State University of New York · USNationwide Children's Hospital · USRoswell Park Comprehensive Cancer Center · USThe Ohio State University · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6M
NCI NIH HHS NCI P30CA016056NCI NIH HHS P30 CA016056
6 · The paper itself

Abstract

Rhabdoid tumor predisposition syndrome (RTPS) is a rare disorder associated with malignant rhabdoid tumor of the kidney (RTK), atypical teratoid rhabdoid tumor (ATRT), and/or other extracranial, extrarenal rhabdoid tumors (EERT), and these pediatric malignancies are difficult to treat. Presently, most of the information regarding clinical manifestations, treatment, and outcomes of rhabdoid tumors comes from large data registries and case series. Our current understanding of treatments for patients with rhabdoid tumors may inform how we approach patients with RTPS. In this manuscript, we review the genetic and clinical features of RTPS and, using known registry data and clinical reports, review associated tumor types ATRT, RTK, and EERT, closing with potential new approaches to treatment. We propose collaborative international efforts to study the use of SMARC (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin)-targeting agents, high-dose consolidative therapy, and age-based irradiation of disease sites in RTPS.

Indexed as

Kidney NeoplasmsRhabdoid TumorTeratomaChildGenetic Predisposition to DiseaseHumansadolescent canceratypical teratoid rhabdoid tumorcancer treatment reviewmalignant rhabdoid tumorpediatric cancerrhabdoid tumor of the kidney

Identifiers

PMID38553892
PMCPMC11039352
OpenAlexW4393345014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.