Evidence map›Paper›PMID 38553754›Full record

ReviewBreast cancer research : BCR2024

Exploring the dynamic interplay between exosomes and the immune tumor microenvironment: implications for breast cancer progression and therapeutic strategies.

Sahar Safaei, Manouchehr Fadaee, Omid Rahbar Farzam, Amirhossein Yari, Elham Poursaei, Cynthia Aslan, Sahar Samemaleki, Dariush Shanehbandi, Behzad Baradaran, Tohid Kazemi

Open access · goldAbstract readReview
In one paragraph

Review in Breast cancer research : BCR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Exosomal ncRNAs in reproductive cancers†.Biology of reproduction · 2025
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sahar SafaeiImmunology Research Center, Tabriz University of Medical Sciences, Gholghasht Ave, Tabriz, Iran.
Manouchehr FadaeeImmunology Research Center, Tabriz University of Medical Sciences, Gholghasht Ave, Tabriz, Iran.
Omid Rahbar FarzamImmunology Research Center, Tabriz University of Medical Sciences, Gholghasht Ave, Tabriz, Iran.
Amirhossein YariImmunology Research Center, Tabriz University of Medical Sciences, Gholghasht Ave, Tabriz, Iran.
Elham PoursaeiBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Cynthia AslanResearch Center for Integrative Medicine in Aging, Tabriz University of Medical Sciences, Tabriz, Iran.
Sahar SamemalekiDepartment of Immunology, Tabriz University of Medical Sciences, Tabriz, Iran.
Dariush ShanehbandiImmunology Research Center, Tabriz University of Medical Sciences, Gholghasht Ave, Tabriz, Iran.
Behzad BaradaranImmunology Research Center, Tabriz University of Medical Sciences, Gholghasht Ave, Tabriz, Iran.
Tohid KazemiImmunology Research Center, Tabriz University of Medical Sciences, Gholghasht Ave, Tabriz, Iran. tohid_kazemi@yahoo.com.
Tabriz University of Medical Sciences · IRIslamic Azad University of Tabriz · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer continues to pose a substantial worldwide health concern, demanding a thorough comprehension of the complex interaction between cancerous cells and the immune system. Recent studies have shown the significant function of exosomes in facilitating intercellular communication and their participation in the advancement of cancer. Tumor-derived exosomes have been identified as significant regulators in the context of breast cancer, playing a crucial role in modulating immune cell activity and contributing to the advancement of the illness. This study aims to investigate the many effects of tumor-derived exosomes on immune cells in the setting of breast cancer. Specifically, we will examine their role in influencing immune cell polarization, facilitating immunological evasion, and modifying the tumor microenvironment. Furthermore, we explore the nascent domain of exosomes produced from immune cells and their prospective involvement in the prevention of breast cancer. This paper focuses on new research that emphasizes the immunomodulatory characteristics of exosomes produced from immune cells. It also explores the possibility of these exosomes as therapeutic agents or biomarkers for the early identification and prevention of breast cancer. The exploration of the reciprocal connections between exosomes formed from tumors and immune cells, together with the rising significance of exosomes derived from immune cells, presents a potential avenue for the advancement of novel approaches in the field of breast cancer therapy and prevention.

Indexed as

Breast NeoplasmsExosomesNeoplasmsCell CommunicationFemaleHumansProspective StudiesTumor MicroenvironmentBreast cancerImmune cellImmune cell-derived exosomesImmunotherapyTumor-derived exosomesTumor microenvironment

Identifiers

PMID38553754
PMCPMC10981336
OpenAlexW4393318861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.