Evidence map›Paper›PMID 38553615›Full record

ArticleNature immunology2024

Thioredoxin is a metabolic rheostat controlling regulatory B cells.

Hannah F Bradford, Thomas C R McDonnell, Alexander Stewart, Andrew Skelton, Joseph Ng, Zara Baig, Franca Fraternali, Deborah Dunn-Walters, David A Isenberg, Adnan R Khan and 2 more

Abstract read
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. IgA2Cell reports. Medicine · 2025
    Trial
  2. B-Cell Aware Analysis of Single-Cell Transcriptomics Data.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  3. Article
  4. Article
  5. A guide to B cell metabolism.Nature reviews. Immunology · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Regulatory B Cells in Tumor Microenvironment.Current issues in molecular biology · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Metabolic Cross Talk in the Tumor Microenvironment.Cancer treatment and research · 2026
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hannah F BradfordInstitute of Immunity and Transplantation, Pears Building, UCL Division of Infection and Immunity, University College London, London, UK. hannah.bradford.12@ucl.ac.uk.ORCID http://orcid.org/0000-0002-6827-3190
Thomas C R McDonnellDepartment of Biochemical Engineering, University College London, London, UK.
Alexander StewartSchool of Biosciences and Medicine, University of Surrey, Guildford, UK.
Andrew SkeltonUCB Pharma, Slough, Berkshire, UK.
Joseph NgInstitute of Structural and Molecular Biology, University College London, London, UK.ORCID http://orcid.org/0000-0002-3617-5211
Zara BaigInstitute of Immunity and Transplantation, Pears Building, UCL Division of Infection and Immunity, University College London, London, UK.
Franca FraternaliInstitute of Structural and Molecular Biology, University College London, London, UK.
Deborah Dunn-WaltersSchool of Biosciences and Medicine, University of Surrey, Guildford, UK.ORCID http://orcid.org/0000-0002-7172-3893
David A IsenbergCentre for Rheumatology, Division of Medicine, University College London, London, UK.ORCID http://orcid.org/0000-0001-9514-2455
Adnan R KhanUCB Pharma, Slough, Berkshire, UK.ORCID http://orcid.org/0000-0001-7126-7157
Claudio MauroInstitute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-3736-0099
Claudia MauriInstitute of Immunity and Transplantation, Pears Building, UCL Division of Infection and Immunity, University College London, London, UK. c.mauri@ucl.ac.uk.ORCID http://orcid.org/0000-0001-9761-2625

Funding

British Heart Foundation (BHF) FS/SBSRF/22/31031RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/P504725/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/T002212/1RCUK | Medical Research Council (MRC) MR/L01257X/2RCUK | MRC | Medical Research Foundation MRF-057-0004-RG-MCDO-C0800
6 · The paper itself

Abstract

Metabolic programming is important for B cell fate, but the bioenergetic requirement for regulatory B (B

Indexed as

Carrier ProteinsCell DifferentiationLupus Erythematosus, SystemicMitochondriaReactive Oxygen SpeciesThioredoxinsAdultAnimalsFemaleHumansMaleMembrane Potential, MitochondrialMiceOxidation-ReductionCarrier ProteinsReactive Oxygen SpeciesThioredoxinsTXNIP protein, humanTXN protein, human

Identifiers

PMID38553615
PMCPMC11065695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.