SynthesisJournal of perinatology : official journal of the California Perinatal Association2024
Caffeine for apnea and prevention of neurodevelopmental impairment in preterm infants: systematic review and meta-analysis.
Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07456670 (Caffeine Therapy in Preterm Infants Born at 28-34 Weeks), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Caffeine Therapy in Preterm Infants Born at 28-34 Weeks: A Pilot Placebo-Controlled Randomized Controlled Trial
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Caffeine and other methylxanthines' impact on bronchiolitis-related apnea in under 12-months-old children-a systematic review with meta-analyses.European journal of pediatrics · 2026Pooled it
- Continuous positive airway pressure versus methylxanthine for apnoea in preterm infants.The Cochrane database of systematic reviews · 2025Pooled it
- Intermittent hypoxia and caffeine in infants born preterm: the ICAF Randomized Clinical Trial.Archives of disease in childhood. Fetal and neonatal edition · 2026Trial
- Personalization of Caffeine Therapy for Apnea of Prematurity: A Potential Role for Sensor Technologies?Sensors (Basel, Switzerland) · 2026Review
- Cumulative caffeine exposure predicts neurodevelopmental outcomes in premature infants.Pediatric research · 2026Article
- Putative mechanisms of caffeine as a neuroprotectant in preterm infants.Pediatric research · 2026Review
- Caffeine addiction: optimising neonatal caffeine use.Pediatric research · 2026Article
- Urine Metabolomics to Predict Bronchopulmonary Dysplasia: A Single-Center Prospective Study.Pediatric pulmonology · 2026Article
- Caffeine prevents airway hyperreactivity in a neonatal mouse model of continuous positive airway pressure.Pediatric research · 2026Article
- Baseline bicarbonate level is associated with apnea of prematurity in preterm neonates with neonatal jaundice: insights from the Medical Information Mart for Intensive Care III (MIMIC-III) database.Translational pediatrics · 2026Article
- Effects of higher caffeine dosing on rates of bronchopulmonary dysplasia and neurodevelopmental outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Caffeine and preterm infants: multiorgan effects and therapeutic creep: scope to optimise dose and timing.Pediatric research · 2026Review
- Development and internal validation of a clinical nomogram for predicting bronchopulmonary dysplasia in preterm infants.Experimental and therapeutic medicine · 2026Article
- Clinical and biological impact of caffeine therapy in premature infants with apnea of prematurity: a prospective observational study.Frontiers in medicine · 2026Article
- Association of caffeine citrate plus vitamin A/D drops with bronchopulmonary dysplasia and respiratory outcomes in preterm infants born at <32 weeks' gestation: a 72-h landmark retrospective cohort study.Frontiers in pediatrics · 2026Article
- Caffeine as a Treatment for Perinatal Hypoxic-Ischemic Brain Injury: The Potential Risks and Benefits.Developmental neuroscience · 2026Review
- Caffeine Protects Against Hyperoxia-Induced Structural Lung Injury and Restores Alveolar Development in Neonatal Rats.Antioxidants (Basel, Switzerland) · 2025Article
- Methylxanthines: The Major Impact of Caffeine in Clinical Practice in Patients Diagnosed with Apnea of Prematurity.Journal of clinical medicine · 2025Review
- Extending the Branches of Neonatal Neurocritical Care.Seminars in perinatology · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This systematic review and meta-analysis evaluated the evidence for dose and effectiveness of caffeine in preterm infants. MEDLINE, EMBASE, CINHAL Plus, CENTRAL, and trial databases were searched to July 2022 for trials randomizing preterm infants to caffeine vs. placebo/no treatment, or low (≤10 mg·kg
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.