Evidence map›Paper›PMID 38553571›Full record

ArticleLeukemia2024

The role of quiescent thymic progenitors in TAL/LMO2-induced T-ALL chemotolerance.

Kevin W O'Connor, Kensei Kishimoto, Irena O Kuzma, Kelsey P Wagner, Jonathan S Selway, Justine E Roderick, Keshab K Karna, Kayleigh M Gallagher, Kai Hu, Haibo Liu and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Kevin W O'ConnorDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0001-5121-623X
Kensei KishimotoDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0002-0745-1969
Irena O KuzmaDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Kelsey P WagnerDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Jonathan S SelwayDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Justine E RoderickDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Keshab K KarnaDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Kayleigh M GallagherDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Kai HuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.ORCID 0000-0002-6555-2581
Haibo LiuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Rui LiDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Michael A BrehmProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Lihua Julie ZhuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
David J CurtisAustralian Centre for Blood Diseases (ACBD), Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.ORCID 0000-0001-9497-0996
Cedric S TremblayDepartment of Immunology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3E 0T5, Canada.ORCID 0000-0003-2396-776X
Michelle A KelliherDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. Michelle.Kelliher@umassmed.edu.ORCID 0000-0001-9211-3659
University of Massachusetts Chan Medical School · USAustralian Centre for HIV and Hepatitis Virology Research · AUCancerCare Manitoba · CA

Funding

Mechanism(s) of TAL-1/SCL-mediated LeukemogenesisR01CA096899 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MICHELLE ALICE KELLIHER · 2004 to 2026
$6.9M
Medical Scientist Training at UMMS Administrative SupplementT32GM107000 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2013 to 2022
$4.9M
Translational Cancer Biology Training ProgramT32CA130807 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MERCURIO, ARTHUR M · 2008 to 2018
$2.7M
Targeting dormant leukemia-initiating cells in T-cell acute lymphoblastic leukemiaF30CA257270 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI O'CONNOR, KEVIN · 2021 to 2024
$153k
NCI NIH HHS F30 CA257270NCI NIH HHS R01 CA096899NCI NIH HHS T32 CA130807NIGMS NIH HHS T32 GM107000
6 · The paper itself

Abstract

Relapse in T-cell acute lymphoblastic leukemia (T-ALL) may signify the persistence of leukemia-initiating cells (L-ICs). Ectopic TAL1/LMO expression defines the largest subset of T-ALL, but its role in leukemic transformation and its impact on relapse-driving L-ICs remain poorly understood. In TAL1/LMO mouse models, double negative-3 (DN3; CD4

Indexed as

Adaptor Proteins, Signal TransducingLIM Domain ProteinsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaT-Cell Acute Lymphocytic Leukemia Protein 1AnimalsHumansMiceNeoplastic Stem CellsThymus GlandAdaptor Proteins, Signal TransducingLIM Domain ProteinsLmo2 protein, mouseTal1 protein, mouseT-Cell Acute Lymphocytic Leukemia Protein 1

Identifiers

PMID38553571
PMCPMC11073972
OpenAlexW4393317016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.