Evidence map›Paper›PMID 38553537›Full record

ArticleScientific reports2024

Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice.

Ayobami Dare, Skylar D King, Shi-You Chen

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ayobami DareDepartment of Surgery, University of Missouri School of Medicine, 1 Hospital Drive, Columbia, MO, 65212, USA.
Skylar D KingDepartment of Surgery, University of Missouri School of Medicine, 1 Hospital Drive, Columbia, MO, 65212, USA.
Shi-You ChenDepartment of Surgery, University of Missouri School of Medicine, 1 Hospital Drive, Columbia, MO, 65212, USA. scqvd@missouri.edu.
University of Missouri Hospital · USHarry S. Truman Memorial Veterans' Hospital · US

Funding

Fortilin, p53, and atherosclerosisR01HL117247 · NHLBI · UNIVERSITY OF WASHINGTON · PI CHEN, SHIYOU, FUJISE, KEN · 2013 to 2023
$4.7M
Novel mechanism of smooth muscle phenotypic modulation and vascular remodelingR01HL119053 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2014 to 2023
$3.8M
Dedicator of cytokinesis 2 in abdominal aortic aneurysmR01HL147313 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2019 to 2022
$2.1M
The mechanistic role of surfactant protein A in smooth muscle cell phenotype modulation and vascular remodelingF32HL159930 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI KING, SKYLAR DAWN · 2021 to 2024
$249k
Novel Mechanisms Underlying the Development of AtherosclerosisI01BX006161 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI Shiyou Chen · 2023 to 2026
–
BLRD VA I01 BX006161NHLBI NIH HHS F32 HL159930NHLBI NIH HHS L30 HL170340NHLBI NIH HHS R01 HL117247NHLBI NIH HHS R01 HL119053NHLBI NIH HHS R01 HL147313
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) remains the most common cause of liver disease in the United States due to the increased incidence of metabolic dysfunction and obesity. Surfactant protein A (SPA) regulates macrophage function, strongly binds to lipids, and is implicated in renal and idiopathic pulmonary fibrosis (IPF). However, the role of SPA in lipid accumulation, inflammation, and hepatic fibrosis that characterize MASLD remains unknown. SPA deficient (SPA

Indexed as

Fatty LiverPulmonary Surfactant-Associated Protein AAnimalsDiet, WesternFatty AcidsFibrosisInflammationLipidsLiver CirrhosisMiceFatty AcidsLipidsPulmonary Surfactant-Associated Protein A

Identifiers

PMID38553537
PMCPMC10980756
OpenAlexW4393316210

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.