ArticleNature communications2024
Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
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Who cites it
29 citing papers in PubMed, 33 citations in OpenAlex.
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Gasdermin D-Mediated Release of IL-33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Long noncoding RNA#61 synergizes with viral PA-X to augment pyroptosis and attenuate the virulence of highly pathogenic H5N1 influenza virus in mice.Journal of virology · 2026Article
- Phellinus pini Polysaccharides Regulate Gut Microbiota-Host Metabolism to Attenuate Influenza-Driven Lung Injury.Current microbiology · 2026Article
- Gasdermin E is dispensable for H1N1 influenza virus pathogenesis in mice.Microbiology spectrum · 2026Article
- Therapeutic Efficacy of the Supersulfide Donor NAC-S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses.Microbiology and immunology · 2026Article
- Dissecting Cell Death Pathways in Influenza A Virus Infection: Comparative Insights from Human Models.Viruses · 2026Review
- IFITM3 deficiency drives SARS-CoV-2 adaptation while preserving variant-specific traits.Nature communications · 2026Article
- Comparative progress on the mechanisms of airway mucosal injury induced by different pathogens: SARS-CoV-2, influenza A virus, and Mycoplasma pneumoniae.Frontiers in cellular and infection microbiology · 2026Review
- Targeting gasdermin D-mediated pyroptosis: a precision anti-inflammatory strategy for acute and chronic lung diseases.Inflammopharmacology · 2026Review
- MARCH E3 Ligases: Understudied Regulators of Pulmonary Immune Function.Journal of respiratory biology and translational medicine · 2026Article
- Exposure to bacterial lipopolysaccharide aggravates H1N1-mediated lung immunopathology via neutrophil extracellular trap formation.Scientific reports · 2025Article
- Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection.Nature communications · 2025Article
- Lung cell fates during influenza.Cell research · 2025Review
- Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection.Signal transduction and targeted therapy · 2025Article
- Pyroptosis in Respiratory Virus Infections: A Narrative Review of Mechanisms, Pathophysiology, and Potential Therapeutic Interventions.Microorganisms · 2025Review
- The Neglected Role of GSDMD C-Terminal in Counteracting Type I Interferon Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cardioprotective effects of AMPK activation in H1N1 influenza virus infection.bioRxiv : the preprint server for biology · 2025Article
- GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses.Journal of virology · 2025Article
- Mechanistic insights into gasdermin-mediated pyroptosis.Nature reviews. Molecular cell biology · 2025Review
Corrections and comments
- Update of
Authors and funding
18 authors at 2 institutions in 1 country.
Samuel Speaks *Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0009-0003-7610-1502
Matthew I McFadden *Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Ashley Zani *Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Abigail SolstadDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Steve LeumiDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Jack E RoettgerDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0009-0006-7584-3020
Adam D KenneyDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Hannah BoneDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-0934-5833
Lizhi ZhangDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Parker J DenzDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-9420-1337
Adrian C EddyDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Amal O AmerDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-4487-7536
Richard T RobinsonDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-4699-515X
Chuanxi CaiDepartment of Surgery, Division of Surgical Science, University of Virginia, Charlottesville, VA, USA.
Jianjie MaDepartment of Surgery, Division of Surgical Science, University of Virginia, Charlottesville, VA, USA.
Emily A HemannDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Adriana ForeroDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA. Adriana.Forero@osumc.edu.ORCID http://orcid.org/0000-0002-2698-658X
Jacob S YountDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA. Jacob.Yount@osumc.edu.ORCID http://orcid.org/0000-0002-6128-4575
The Ohio State University · USUniversity of Virginia · US
Funding
Mechanisms of innate resistance to virus infectionsR01AI130110 · NIAID · OHIO STATE UNIVERSITY · PI Jacob Yount · 2017 to 2026
$4.3MMechanisms of lung and cardiac pathology in SARS-CoV-2 infectionsR01HL168501 · NHLBI · OHIO STATE UNIVERSITY · PI Amal O Amer, Jacob Yount · 2023 to 2026
$2.9MProtein therapy to treat virus induced cardiopulmonary injuryR01HL157215 · NHLBI · UNIVERSITY OF VIRGINIA · PI CAI, CHUANXI, MA, JIANJIE · 2022 to 2025
$2.7MMechanistic characterization of a new master regulator of cardiac virus infectionsR01HL154001 · NHLBI · OHIO STATE UNIVERSITY · PI ACCORNERO, FEDERICA, YOUNT, JACOB · 2020 to 2023
$2.3MIdentification of novel type III IFN regulatory pathwaysR35GM150806 · NIGMS · OHIO STATE UNIVERSITY · PI Adriana Forero · 2023 to 2026
$1.6MRIG-I-like receptor regulation of pulmonary inflammation and homeostasisR35GM150503 · NIGMS · OHIO STATE UNIVERSITY · PI Emily Ann Hemann · 2023 to 2026
$1.6MInterdisciplinary Program in Microbe-Host BiologyT32AI165391 · NIAID · OHIO STATE UNIVERSITY · PI RAJENDAR K DEORA, Daniel J Wozniak · 2022 to 2026
$1.5MEstablishing a relevant mouse model with susceptibility to non-adapted influenza viruses for vaccine challenge studiesR21AI151230 · NIAID · OHIO STATE UNIVERSITY · PI YOUNT, JACOB · 2020 to 2021
$409kNHLBI NIH HHS R01 HL154001NHLBI NIH HHS R01 HL157215NHLBI NIH HHS R01 HL168501NIAID NIH HHS R01 AI130110NIAID NIH HHS R21 AI151230NIAID NIH HHS T32 AI165391NIGMS NIH HHS R35 GM150503NIGMS NIH HHS R35 GM150806
Abstract
Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection. Ablation of GSDMD in knockout (KO) mice (Gsdmd
Indexed as
NeutrophilsOrthomyxoviridaeAnimalsGasderminsInflammasomesInflammationMicePhosphate-Binding ProteinsGasderminsInflammasomesPhosphate-Binding Proteins
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